Analysis of the reactions used for the preparation of drug candidate molecules (original) (raw)
* Corresponding authors
a GlaxoSmithKline Pharmaceuticals, Old Powder Mills, nr. Leigh, Tonbridge, UK
E-mail: john.s.carey@gsk.com
Fax: 44 (0)1732 372355
Tel: 44 (0)1732 372245
b AstraZeneca PR&D, Silk Road Business Park, Macclesfield, Cheshire, UK
E-mail: dave.laffan@astrazeneca.com
Fax: 44 (0)1625 500780
Tel: 44 (0)1625 517483
c AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, UK
E-mail: colin.thomson@astrazeneca.com
Fax: 44 (0)1509 645588
Tel: 44(0)1509 644273
d Pfizer Global R&D, Sandwich, Kent, UK
E-mail: mike.t.williams@pfizer.com
Fax: 44 (0)1304 655586
Tel: 44 (0)1304 646383
Abstract
The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies. To do this a survey was carried out of chemical syntheses within the Process Chemistry R&D departments of GlaxoSmithKline, AstraZeneca and Pfizer.
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Article information
DOI
https://doi.org/10.1039/B602413K
Article type
Perspective
Submitted
16 Feb 2006
First published
03 May 2006
Download Citation
Org. Biomol. Chem., 2006,4, 2337-2347
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Analysis of the reactions used for the preparation of drug candidate molecules
J. S. Carey, D. Laffan, C. Thomson and M. T. Williams,Org. Biomol. Chem., 2006, 4, 2337DOI: 10.1039/B602413K
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