Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes (original) (raw)
* Corresponding authors
a Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, ON, Canada
E-mail: John.Pezacki@nrc-cnrc.gc.ca
Fax: +1 613-952-0068
Tel: +1 613-993-7253
b Department of Chemistry, University of Ottawa, 10 Marie-Curie, Ottawa, ON, Canada
Abstract
Strain-promoted cycloadditions of nitrones with cyclooctynes (_k_2 = 1.5 M−1 s−1 at 25 °C) are up to 25 times more rapid than comparable reactions of azides.
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Article information
DOI
https://doi.org/10.1039/B921630H
Article type
Communication
Submitted
15 Oct 2009
Accepted
08 Dec 2009
First published
23 Dec 2009
Download Citation
Chem. Commun., 2010,46, 931-933
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Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes
C. S. McKay, J. Moran and J. P. Pezacki,Chem. Commun., 2010, 46, 931DOI: 10.1039/B921630H
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