Trace metal imaging with high spatial resolution: Applications in biomedicine (original) (raw)

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Department of Medicine, College of Medicine, University of Cincinnati

, Cincinnati, OH 45267,

USA

Department of Surgery, Vascular Surgery Division, University of Texas Health Science Center at San Antonio

, San Antonio, TX 78229,

USA

. Fax: (210) 567-1762; Tel: (210) 567-5715

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Department of Chemistry, College of Arts and Sciences, University of Cincinnati

, Cincinnati, OH 45267,

USA

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X-Ray Science Division, Argonne National Laboratory

, Argonne, Illinois 60439,

USA

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,

Institute of Neurosciences and Medicine

, Forschungszentrum Juelich, D-52425, Juelich,

Germany

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Central Division of Analytical Chemistry

, Forschungszentrum Juelich, D-52425, Juelich,

Germany

, (www.brainmet.com)

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Received:

14 September 2010

Accepted:

04 November 2010

Published:

07 December 2010

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Zhenyu Qin, Joseph A Caruso, Barry Lai, Andreas Matusch, J Sabine Becker, Trace metal imaging with high spatial resolution: Applications in biomedicine, Metallomics, Volume 3, Issue 1, January 2011, Pages 28–37, https://doi.org/10.1039/c0mt00048e
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Abstract

New generations of analytical techniques for imaging of metals are pushing hitherto boundaries of spatial resolution and quantitative analysis in biology. Because of this, the application of these imaging techniques described herein to the study of the organization and dynamics of metal cations and metal-containing biomolecules in biological cell and tissue is becoming an important issue in biomedical research. In the current review, three common metal imaging techniques in biomedical research are introduced, including synchrotron X-ray fluorescence (SXRF) microscopy, secondary ion mass spectrometry (SIMS), and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). These are exemplified by a demonstration of the dopamine-Fe complexes, by assessment of boron distribution in a boronneutron capture therapy cell model, by mapping Cu and Zn in human brain cancer and a rat brain tumor model, and by the analysis of metal topography within neuromelanin. These studies have provided solid evidence that demonstrates that the sensitivity, spatial resolution, specificity, and quantification ability of metal imaging techniques is suitable and highly desirable for biomedical research. Moreover, these novel studies on the nanometre scale (e.g., of individual single cells or cell organelles) will lead to a better understanding of metal processes in cells and tissues.

Graphical Abstract

Recent publications demonstrate that the sensitivity, spatial resolution, specificity, and quantification of bioimagining of metals are suitable for biomedical research.

© The Royal Society of Chemistry 2011

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open\_access/funder\_policies/chorus/standard\_publication\_model)

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