Nanomechanical identification of liquid reagents in a microfluidic channel (original) (raw)
* Corresponding authors
a Department of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark
E-mail: anja.boisen@nanotech.dtu.dk
b Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada
E-mail: thundat@ualberta.ca
c Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada
Abstract
Integration of promising technologies that can enhance sensitivity, selectivity, and throughput into micro total analysis systems (μTAS) are important in making them useful in precise screening of reaction byproducts in analytical chemistry, cellular biology and pharmaceutical industries. But unfortunately so far a method to precisely determine molecular signatures of reagents is missing in μTAS. We have developed a technique whereby molecular signatures of 50 pL of liquid reagents confined within a bimetallic microchannel cantilever can be obtained. This is achieved using wavelength dependent mechanical bending of the cantilever under infrared (IR) radiation. This technique also allows simultaneous physical characterization of the liquid reagent using variations in resonance frequency. It is useful in lab-on-a-chip devices and has a myriad of applications in drug screening, bioreactor monitoring, and petrochemical analysis.
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Article information
DOI
https://doi.org/10.1039/C3LC51273H
Article type
Paper
Submitted
14 Nov 2013
Accepted
06 Jan 2014
First published
06 Jan 2014
Download Citation
Lab Chip, 2014,14, 1302-1307
Author version available
Permissions
Nanomechanical identification of liquid reagents in a microfluidic channel
M. Faheem Khan, S. Kim, D. Lee, S. Schmid, A. Boisen and T. Thundat,Lab Chip, 2014, 14, 1302DOI: 10.1039/C3LC51273H
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