Recent development of biotin conjugation in biological imaging, sensing, and target delivery (original) (raw)
* Corresponding authors
a Department of Chemistry, Korea University, Seoul 136-701, South Korea
E-mail: jongskim@korea.ac.kr
b Laboratory of Stem Cells and Tissue Regeneration, Division of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul, South Korea
E-mail: jhkim@korea.ac.kr
c Graduate School of Medical Science, Kyung Hee University, Yongin, South Korea
E-mail: kangch@khu.ac.kr
Abstract
Despite encouraging results from preliminary studies of anticancer therapies, the lack of tumor specificity remains an important issue in the modern pharmaceutical industry. New findings indicate that biotin or biotin-conjugates could be favorably assimilated by tumor cells that over-express biotin-selective transporters. Furthermore, biotin can form stable complexes with avidin and its bacterial counterpart streptavidin. The strong bridging between avidin and biotin moieties on other molecules is a proven adaptable tool with broad biological applications. Under these circumstances, a biotin moiety is certainly an attractive choice for live-cell imaging, biosensing, and target delivery.
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Article information
DOI
https://doi.org/10.1039/C5CC03075G
Article type
Feature Article
Submitted
14 Apr 2015
Accepted
13 May 2015
First published
13 May 2015
Download Citation
Chem. Commun., 2015,51, 10403-10418
Permissions
Recent development of biotin conjugation in biological imaging, sensing, and target delivery
W. X. Ren, J. Han, S. Uhm, Y. J. Jang, C. Kang, J. Kim and J. S. Kim,Chem. Commun., 2015, 51, 10403DOI: 10.1039/C5CC03075G
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