Brain region-specific metabolite networks regulate antidepressant effects of venlafaxine (original) (raw)
* Corresponding authors
a Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, China
E-mail: xiepeng@cqmu.edu.cn
Fax: +86-23-68485111
Tel: +86-23-68485490
b Chongqing Key Laboratory of Neurobiology, Chongqing, China
c Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China
d Key Laboratory of Laboratory Medical Diagnostics of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, China
e Department of Neurology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia, China
f Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Abstract
Venlafaxine (VLX) is one of the most commonly prescribed clinical antidepressants. Although the initial targets of venlafaxine are known to be neurotransmitter systems, the mechanisms underlying chronic therapeutic effects in different key brain regions have not been fully clarified. In this study, we used depression-related behavior to evaluate the effects of chronic VLX therapy in rats. Gas chromatography-mass spectrometry-based metabolomics was used to characterize metabolomic responses to VLX in the hippocampus and prefrontal cortex. The results demonstrated significant differences in despair behaviors between VLX-treated and control groups of rats, and the metabolic profiles of both the hippocampus and prefrontal cortex were significantly altered after VLX treatment. Furthermore, the altered metabolites had significant brain region specificities, and the altered metabolites in the hippocampus had significant correlations with the despair behaviors. The results obtained from such a metabolic profiling strategy potentially provide a unique perspective on the molecular mechanisms of VLX, and these findings could have important implications for antidepressant drug discovery efforts.
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Article information
DOI
https://doi.org/10.1039/C7RA08726H
Article type
Paper
Submitted
07 Aug 2017
Accepted
20 Sep 2017
First published
29 Sep 2017
This article is Open Access
Download Citation
RSC Adv., 2017,7, 46358-46369
Permissions
Brain region-specific metabolite networks regulate antidepressant effects of venlafaxine
S. Bai, Q. Hu, Z. Chen, Z. Liang, W. Wang, P. Shen, T. Wang, H. Wang and P. Xie,RSC Adv., 2017, 7, 46358DOI: 10.1039/C7RA08726H
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