AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice (original) (raw)
* Corresponding authors
a Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, P. R. China
E-mail: qixiangyang85@sina.com
Tel: +86 574 88222461
b College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, P. R. China
c The School of Food and Chemical Engineering, Beijing Technology & Business University (BTBU), Beijing 100048, P. R. China
Abstract
Previous studies suggested the anti-diabetic effect of mogrosides in type 1 diabetes. To evaluate the potential effect of mogrosides in type 2 diabetes, we herein investigated the hypoglycemic and hypolipidemic effects and the underlying mechanism of mogroside-rich extract (MGE) using a high-fat diet in combination with streptozotocin (STZ)-induced diabetic model. MGE feeding for 5 weeks did not result in any obvious impact on the body weight and energy intake, but caused a moderate decrease of organ index in diabetic mice. MGE-supplemented diabetic mice showed a notable reduction of fasting blood glucose (FBG), glycated serum protein (GSP), serum insulin, homeostasis model assessment-insulin resistance (HOMA-IR), and serum atherogenic lipid profiles in a dose-dependent manner, whereas significant increases in the anti-atherogenic lipid profile, insulin sensitivity, glucose and insulin tolerance capacity with high dose (300 mg kg−1) MGE were observed (P < 0.01). Besides, hepatocyte polymorphism, lipid accumulation and steatosis were ameliorated and restored to near normal at the high dose. Furthermore, hepatic 5′AMP-activated protein kinase (AMPK) signaling was dose-dependently activated. Accordingly, the mRNA levels of hepatic gluconeogenic and lipogenic genes were downregulated and fat oxidation-associated genes were upregulated. These findings suggest that the hypoglycemic and hypolipidemic activities of MGE are probably attributed to the attenuation of insulin resistance and activation of hepatic AMPK signaling.
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Article information
DOI
https://doi.org/10.1039/C8FO01486H
Article type
Paper
Submitted
24 Jul 2018
Accepted
12 Nov 2018
First published
15 Nov 2018
Download Citation
Food Funct., 2019,10, 151-162
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AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice
H. Liu, X. Qi, K. Yu, A. Lu, K. Lin, J. Zhu, M. Zhang and Z. Sun,Food Funct., 2019, 10, 151DOI: 10.1039/C8FO01486H
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