Determination of a non-volatile nitrosamine by using denitrosation and a chemiluminescence analyser (original) (raw)

Abstract

A method has been devised for the determination of _N_-nitrososarcosine, representative of the group of non-volatile nitrosamines of physiological origin, whereby the nitrosamine is denitrosated with hydrogen bromide to form the volatile nitrosyl bromide. After dehalogenation in a heated converter, the nitrosamine can be determined as nitric oxide by using a chemiluminescence analyser, the response being linear up to at least 200 _µ_g. The limit of detection is below 6 ng, and is therefore much lower than that for the determination of _N_-nitrososarcosine as inorganic nitrite in solution after denitrosation. A response is also obtained from inorganic nitrite but this can be differentiated from that of _N_-nitrososarcosine by the use of acetic acid alone, prior to denitrosation with hydrogen bromide in the same solvent.

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Article information

DOI

https://doi.org/10.1039/AN9760100742

Article type

Paper

Download Citation

Analyst, 1976,101, 742-748

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