Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex (original) (raw)
* Corresponding authors
a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: sb10031@cam.ac.uk
Fax: +44 1223 336913
Tel: +44 1223 336347
b School of Clinical Medicine, University of Cambridge, Cambridge, UK
Abstract
Herein, we show that a naturally occurring RNA G-quadruplex element within the 5′ UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5′ UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.
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Article information
DOI
https://doi.org/10.1039/C002418J
Article type
Paper
Submitted
04 Feb 2010
Accepted
06 Apr 2010
First published
30 Apr 2010
Download Citation
Org. Biomol. Chem., 2010,8, 2771-2776
Permissions
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
A. Bugaut, R. Rodriguez, S. Kumari, S. D. Hsu and S. Balasubramanian,Org. Biomol. Chem., 2010, 8, 2771DOI: 10.1039/C002418J
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