Recent advances in molecular imprinting technology: current status, challenges and highlighted applications (original) (raw)
* Corresponding authors
a Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
E-mail: lxchen@yic.ac.cn
Fax: +86-535-2109130
Tel: +86-535-2109130
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China
Abstract
Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).
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Article information
DOI
https://doi.org/10.1039/C0CS00084A
Article type
Critical Review
Submitted
18 Aug 2010
First published
28 Feb 2011
Download Citation
Chem. Soc. Rev., 2011,40, 2922-2942
Permissions
Recent advances in molecular imprinting technology: current status, challenges and highlighted applications
L. Chen, S. Xu and J. Li,Chem. Soc. Rev., 2011, 40, 2922DOI: 10.1039/C0CS00084A
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