Real-time, in vivo monitoring and pharmacokinetics of valproic acidvia a novel biomarker in exhaled breath (original) (raw)
* Corresponding authors
a Department of Chemistry and Applied Biosciences, ETH Zürich, CH-8093 Zürich, Switzerland
E-mail: zenobi@org.chem.ethz.ch
Fax: +41 44 632 1292
Tel: +41 44 632 4376
b Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, CH-8008 Zürich, Switzerland
c Department of Applied Chemistry, East China Institute of Technology, Fuzhou 344000, China
d Department of Chemistry, University of Bremen, Loebener Str. NW 2C, D-28334 Bremen, Germany
Abstract
Extractive electrospray ionization mass spectrometry is shown to allow real-time, _in vivo_drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy.
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Article information
DOI
https://doi.org/10.1039/C1CC10343A
Article type
Communication
Submitted
18 Jan 2011
Accepted
10 Feb 2011
First published
04 Mar 2011
Download Citation
Chem. Commun., 2011,47, 4884-4886
Permissions
Real-time, in vivo monitoring and pharmacokinetics of valproic acid_via_ a novel biomarker in exhaled breath
G. Gamez, L. Zhu, A. Disko, H. Chen, V. Azov, K. Chingin, G. Krämer and R. Zenobi,Chem. Commun., 2011, 47, 4884DOI: 10.1039/C1CC10343A
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