Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms (original) (raw)
* Corresponding authors
a Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, P.R. China
E-mail: zhmiao@mail.shcnc.ac.cn
Fax: +86-21-50806820
Tel: + 86-21-50806820
b Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, P.R. China
E-mail: ycli@mail.shcnc.ac.cn
Fax: + 86-21-50807288
Tel: + 86-21-50807288
Abstract
Covering: 1972 to 2011
Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure–activity relationships, pharmacology, and clinical development of triptolide in the last forty years.
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Article information
DOI
https://doi.org/10.1039/C2NP00088A
Article type
Review Article
Submitted
09 Nov 2011
First published
23 Jan 2012
Download Citation
Nat. Prod. Rep., 2012,29, 457-475
Permissions
Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms
Z. Zhou, Y. Yang, J. Ding, Y. Li and Z. Miao,Nat. Prod. Rep., 2012, 29, 457DOI: 10.1039/C2NP00088A
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