Industrial use of immobilized enzymes (original) (raw)
* Corresponding authors
a DuPont Central Research and Development Department, Experimental Station, E328/260B, P.O. Box 80328, Wilmington, DE 19880-0328, USA
E-mail: Robert.DiCosimo@dupont.com
b DuPont Industrial Biosciences, 925 Page Mill Road, Palo Alto, CA 94304, USA
Abstract
Although many methods for enzyme immobilization have been described in patents and publications, relatively few processes employing immobilized enzymes have been successfully commercialized. The cost of most industrial enzymes is often only a minor component in overall process economics, and in these instances, the additional costs associated with enzyme immobilization are often not justified. More commonly the benefit realized from enzyme immobilization relates to the process advantages that an immobilized catalyst offers, for example, enabling continuous production, improved stability and the absence of the biocatalyst in the product stream. The development and attributes of several established and emerging industrial applications for immobilized enzymes, including high-fructose corn syrup production, pectin hydrolysis, debittering of fruit juices, interesterification of food fats and oils, biodiesel production, and carbon dioxide capture are reviewed herein, highlighting factors that define the advantages of enzyme immobilization.
- This article is part of the themed collection:Enzyme immobilisation
You have access to this article
Please wait while we load your content... Something went wrong. Try again?
Article information
DOI
https://doi.org/10.1039/C3CS35506C
Article type
Review Article
Submitted
10 Dec 2012
First published
25 Feb 2013
Download Citation
Chem. Soc. Rev., 2013,42, 6437-6474
Permissions
Industrial use of immobilized enzymes
R. DiCosimo, J. McAuliffe, A. J. Poulose and G. Bohlmann,Chem. Soc. Rev., 2013, 42, 6437DOI: 10.1039/C3CS35506C
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.