Recent advances in multifunctional magnetic nanoparticles and applications to biomedical diagnosis and treatment (original) (raw)
* Corresponding authors
a Ministry-of-Education Key Laboratory of Green Preparation and Application for Materials, Hubei University, Wuhan, 430062, P. R. China
E-mail: zushun25@yahoo.com.cn, paul.chu@cityu.edu.hk
Fax: 86-27-88665610
Tel: 852-34427724
b Department of Physics & Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China
Abstract
By virtue of the unique magnetic properties and other functionalities, multifunctional magnetic nanoparticles (MNPs) are very promising in diagnostic and therapeutic applications. This review summarizes recent developments pertaining to the synthesis of MNPs with focus on the various surface modification strategies such as chemical synthesis, self-assembly, and ligand exchange. Recent applications of MNPs to multimodal imaging including magnetic resonance imaging (MRI)/optical imaging (fluorescent dyes, quantum dots (QDs), near-infrared absorption and up-conversion luminescence, MRI/positron emission tomography (PET), MRI/X-ray computed tomography (CT), and triple modality imaging are discussed. In addition, targeted drug and gene delivery, hyperthermia treatment for cancer, and other biomedical diagnosis rendered possible by MNPs are described.
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Article information
DOI
https://doi.org/10.1039/C3RA40348C
Article type
Review Article
Submitted
23 Jan 2013
Accepted
21 Mar 2013
First published
25 Mar 2013
Download Citation
RSC Adv., 2013,3, 10598-10618
Permissions
Recent advances in multifunctional magnetic nanoparticles and applications to biomedical diagnosis and treatment
K. Yan, P. Li, H. Zhu, Y. Zhou, J. Ding, J. Shen, Z. Li, Z. Xu and P. K. Chu,RSC Adv., 2013, 3, 10598DOI: 10.1039/C3RA40348C
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