Fluorinase mediated C–18F bond formation, an enzymatic tool for PET labelling (original) (raw)
* Corresponding authors
a University of St Andrews, School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UK
E-mail: do1@st-andrews.ac.uk
Fax: 01334 463800
Tel: 01334 467171
b GlaxoSmithKline, Addenbrooke's Hospital, Hills Road, Cambridge, UK
E-mail: Antony_D_Gee@gsk.com
Fax: 01223 296063
Tel: 01223 296120
Abstract
The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-5′-fluoro-5′-deoxyadenosine, [18F]-5′-fluoro-5′-deoxyinosine and [18F]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.
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Article information
DOI
https://doi.org/10.1039/B516861A
Article type
Communication
Submitted
28 Nov 2005
Accepted
10 Jan 2006
First published
18 Jan 2006
Download Citation
Chem. Commun., 2006, 652-654
Permissions
Fluorinase mediated C–18F bond formation, an enzymatic tool for PET labelling
H. Deng, S. L. Cobb, A. D. Gee, A. Lockhart, L. Martarello, R. P. McGlinchey, D. O'Hagan and M. Onega,Chem. Commun., 2006, 652DOI: 10.1039/B516861A
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