Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues (original) (raw)
* Corresponding authors
a Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
E-mail: peter.northcote@vuw.ac.nz
Fax: +64 4 463 5237
Tel: +64 4 463 5960
b University Chemical Laboratory, University of Cambridge, Cambridge, United Kingdom
Abstract
Two new peloruside congeners (3 and 4) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli. Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1.
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Article information
DOI
https://doi.org/10.1039/C0OB01127D
Article type
Paper
Submitted
06 Dec 2010
Accepted
21 Mar 2011
First published
23 Mar 2011
Download Citation
Org. Biomol. Chem., 2011,9, 4456-4466
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Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues
A. J. Singh, M. Razzak, P. Teesdale-Spittle, T. N. Gaitanos, A. Wilmes, I. Paterson, J. M. Goodman, J. H. Miller and P. T. Northcote,Org. Biomol. Chem., 2011, 9, 4456DOI: 10.1039/C0OB01127D
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