ZnO nanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility (original) (raw)
* Corresponding authors
a Department of Chemistry and Kanbar Laboratory for Nanomaterials, Center for Advanced Materials and Nanotechnology, Bar-Ilan University, Ramat-Gan, Israel
E-mail: gedanken@mail.biu.ac.il
Fax: +972-3-7369928
Tel: +972-3-5318315
b The Biofilm Research Laboratory, Center for Advanced Materials and Nanotechnology, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
E-mail: ehud.banin@biu.ac.il
Fax: +972-3-7384053
Tel: +972-3-5317288
Abstract
Nanotechnology is providing new ways to manipulate the structure and chemistry of surfaces to inhibit bacterial colonization. In this study, we evaluated the ability of glass slides coated with zinc oxide (ZnO) nanoparticles to restrict the biofilm formation of common bacterial pathogens. The generation of hydroxyl radicals, originating from the coated surface, was found to play a key role in antibiofilm activity. Furthermore, we evaluated the ability of the nanoparticle coating to enhance the antibacterial activity of commonly-used antibiotics. The ZnO nanoparticles were synthesized and deposited on the surface of glass slides using a one-step ultrasound irradiation process. Several physico-chemical surface characterization methods were performed to prove the long-term stability and homogenity of the coated films. Collectively, our findings may open a new door for utilizing ZnO nanoparticle films as antibiofilm coating of surfaces, thus providing a versatile platform for a wide range of applications both in medical and industrial settings, all of which are prone to bacterial colonization.
- This article is part of the themed collection:Chemistry in the battle against infections
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Article information
DOI
https://doi.org/10.1039/C2RA00602B
Article type
Paper
Submitted
17 Aug 2011
Accepted
04 Dec 2011
First published
26 Jan 2012
Download Citation
RSC Adv., 2012,2, 2314-2321
Permissions
ZnOnanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility
G. Applerot, J. Lellouche, N. Perkas, Y. Nitzan, A. Gedanken and E. Banin,RSC Adv., 2012, 2, 2314DOI: 10.1039/C2RA00602B
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