Light-inducible molecular beacons for spatio-temporally highly defined activation (original) (raw)
* Corresponding authors
a Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany
E-mail: heckel@uni-frankfurt.de
b Rheinische Friedrich Wilhelms-Universität Bonn, Institute for Physical and Theoretical Chemistry, Wegelerstr. 12, 53115 Bonn, Germany
E-mail: u.kubitscheck@uni-bonn.de
Abstract
We have developed a new molecular beacon design that requires an additional UV pulse for fluorescence activation. This improves the signal-to-noise ratio tremendously compared to previous approaches and allows for a precise control of the time point and location of RNA labelling.
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Article information
DOI
https://doi.org/10.1039/C3CC42420K
Article type
Communication
Submitted
03 Apr 2013
Accepted
23 Apr 2013
First published
24 Apr 2013
Download Citation
Chem. Commun., 2013,49, 5375-5377
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Light-inducible molecular beacons for spatio-temporally highly defined activation
J. S. Rinne, T. P. Kaminski, U. Kubitscheck and A. Heckel,Chem. Commun., 2013, 49, 5375DOI: 10.1039/C3CC42420K
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