Biomaterials for mRNA delivery (original) (raw)
* Corresponding authors
a Laboratory for Nanoengineering & Drug Delivery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
E-mail: jinjun.shi@zeus.bwh.harvard.edu
b Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
E-mail: bruce.zetter@childrens.harvard.edu
Abstract
Messenger RNA (mRNA) has recently emerged with remarkable potential as an effective alternative to DNA-based therapies because of several unique advantages. mRNA does not require nuclear entry for transfection activity and has a negligible chance of integrating into the host genome which excludes the possibility of potentially detrimental genomic alternations. Chemical modification of mRNA has further enhanced its stability and decreased its activation of innate immune responses. Additionally, mRNA has been found to have rapid expression and predictable kinetics. Nevertheless, the ubiquitous application of mRNA remains challenging given its unfavorable attributes, such as large size, negative charge and susceptibility to enzymatic degradation. Further refinement of mRNA delivery modalities is therefore essential for its development as a therapeutic tool. This review provides an exclusive overview of current state-of-the-art biomaterials and nanotechnology platforms for mRNA delivery, and discusses future prospects to bring these exciting technologies into clinical practice.
- This article is part of the themed collection:mRNA vaccines against COVID-19: Celebrating the 2023 Nobel Prize in Physiology or Medicine
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Article information
DOI
https://doi.org/10.1039/C5BM00198F
Article type
Review Article
Submitted
21 Jun 2015
Accepted
04 Aug 2015
First published
17 Aug 2015
Download Citation
Biomater. Sci., 2015,3, 1519-1533
Permissions
Biomaterials for mRNA delivery
M. A. Islam, E. K. G. Reesor, Y. Xu, H. R. Zope, B. R. Zetter and J. Shi,Biomater. Sci., 2015, 3, 1519DOI: 10.1039/C5BM00198F
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