Approaches to target tractability assessment – a practical perspective (original) (raw)
* Corresponding authors
a Computational and Modelling Sciences, Platform Technology and Sciences, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, USA
b NCE Molecular Discovery, Platform Technology and Sciences, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
E-mail: mike.m.hann@gsk.com
c In vitro/In vivo Translation Sciences, Platform Technology and Sciences, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, USA
d Target Sciences Computational Biology, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
e Computational and Modelling Sciences, Platform Technology and Sciences, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
Abstract
The assessment of the suitability of novel targets to intervention by different modalities, e.g. small molecules or antibodies, is increasingly seen as important in helping to select the most progressable targets at the outset of a drug discovery project. This perspective considers differing aspects of tractability and how it can be assessed using in silico and experimental approaches. We also share some of our experiences in using these approaches.
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Article information
DOI
https://doi.org/10.1039/C7MD00633K
Article type
Review Article
Submitted
15 Dec 2017
Accepted
13 Feb 2018
First published
14 Feb 2018
Download Citation
Med. Chem. Commun., 2018,9, 606-613
Permissions
Approaches to target tractability assessment – a practical perspective
K. K. Brown, M. M. Hann, A. S. Lakdawala, R. Santos, P. J. Thomas and K. Todd,Med. Chem. Commun., 2018, 9, 606DOI: 10.1039/C7MD00633K
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