Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications (original) (raw)
* Corresponding authors
a College of Food Science and Technology and MOE Key Laboratory of Environment Correlative Dietology, Huazhong Agricultural University, Wuhan 430070, P. R. China
E-mail: xiongsb@mail.hzau.edu.cn, huyang@mail.hzau.edu.cn
Fax: +86-27-87288375
Tel: +86-27-87288375
b Collaborative Innovation Center for Efficient and Health Production of Fisheries in Hunan Province, Changde 415000, P. R. China
c Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Engineering, Sun Yat-sen University, Guangzhou 510006, P. R. China
Abstract
The desired mechanical and biological performances of collagen that have led to its broad application as a building block in the biomedical field attributed to its intrinsic hierarchical structure from the nanoscale to macroscale, are discussed herein. Modulating the self-assembly process using regulatory factors can lead to obtaining collagenous materials with tuneable functional performance, which can then determine distinctive cellular responses. Herein, we present an overview of the corresponding characterization techniques used to detect the changes in light transmittance, architecture and mechanics during collagen fibrillogenesis. By combining regulatory parameters with characterization methods, researchers can selectively fabricate collagenous biomaterials with various functional responses.
- This article is part of the themed collection:Recent Review Articles
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Article information
DOI
https://doi.org/10.1039/C7TB02999C
Article type
Review Article
Submitted
17 Nov 2017
Accepted
29 Mar 2018
First published
03 Apr 2018
Download Citation
J. Mater. Chem. B, 2018,6, 2650-2676
Permissions
Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications
S. Zhu, Q. Yuan, T. Yin, J. You, Z. Gu, S. Xiong and Y. Hu,J. Mater. Chem. B, 2018, 6, 2650DOI: 10.1039/C7TB02999C
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