Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer (original) (raw)

Author affiliations

* Corresponding authors

a Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Koyama-Minami 4-101, Tottori 680-8552, Japan
E-mail: ma2ra-k@tottori-u.ac.jp

b Centre for Research on Green Sustainable Chemistry, Tottori University, Koyama-Minami 4-101, Tottori 680-8552, Japan

c Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan

Abstract

Anionic artificial viral capsids were self-assembled from β-annulus-EE peptide, then complexed with lipid-bilayer-containing cationic lipids via electrostatic interaction to form enveloped artificial viral capsids. The critical aggregation concentration of the enveloped artificial viral capsid was significantly lower than that of the uncomplexed artificial viral capsid, indicating that the lipid bilayer stabilised the capsid structure.

Graphical abstract: Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer

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Article information

DOI

https://doi.org/10.1039/D0CC02622K

Article type

Communication

Submitted

11 Apr 2020

Accepted

28 May 2020

First published

28 May 2020

Download Citation

Chem. Commun., 2020,56, 7092-7095

Permissions

Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer

H. Furukawa, H. Inaba, F. Inoue, Y. Sasaki, K. Akiyoshi and K. Matsuura,Chem. Commun., 2020, 56, 7092DOI: 10.1039/D0CC02622K

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