Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis (original) (raw)

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• Published: 10 December 1999

British Journal of Cancer volume 82, pages 9–15 (2000)Cite this article

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Abstract

The aim of this study was to clarify the role of APC and K- ras mutations in non-polypoid colorectal tumorigenesis. DNA from 63 adenomas (31 polypoid, 17 superficial elevated, 15 superficial depressed), 66 submucosally invasive carcinomas (47 polypoid, 19 non-polypoid) and 34 advanced carcinomas were examined for K- ras codon 12 point mutations and APC mutations in the mutation cluster region. K- ras mutation: the frequency in superficial depressed adenomas was lower than that in polypoid adenomas (0% vs 31%: P = 0.018). The frequency in non-polypoid carcinomas was lower than that in polypoid carcinomas (11% vs 56%: P = 0.0008), and was relatively low compared with that in polypoid adenomas (11% vs 31%). APC mutation: the frequency in superficial depressed adenomas was lower than that in polypoid adenomas (7% vs 43%: P = 0.016), and that in polypoid carcinomas was similar to that in non-polypoid carcinomas. Polypoid adenomas, polypoid carcinomas and advanced carcinomas had almost the same frequency. There may be some pathway other than the conventional adenoma-carcinoma sequence in development of non-polypoid carcinomas. The precursors of most non-polypoid carcinomas are considered to be de novo or superficial depressed adenomas. In this non-polypoid pathway, APC mutation seems to be requisite but K- ras mutation not. It is possible that new APC mutations are acquired after the development of superficial depressed adenomas. © Copyright 2000 Cancer Research Campaign

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Authors and Affiliations

1. Department of Surgical Oncology, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan
   N Umetani, S Sasaki, T Watanabe & K Matsuda
2. First Department of Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan
   T Masaki
3. Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, 170-8455, Tokyo, Japan
   T Muto

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1. N Umetani
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2. S Sasaki
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3. T Masaki
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4. T Watanabe
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5. K Matsuda
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6. T Muto
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Umetani, N., Sasaki, S., Masaki, T. et al. Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis.Br J Cancer 82, 9–15 (2000). https://doi.org/10.1054/bjoc.1999.0869

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• Received: 22 March 1999
• Revised: 10 June 1999
• Accepted: 07 July 1999
• Published: 10 December 1999
• Issue Date: 01 January 2000
• DOI: https://doi.org/10.1054/bjoc.1999.0869

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