HPV types and cofactors causing cervical cancer in Peru (original) (raw)

• Regular Article
• Open access
• Published: 02 October 2001
• N Muñoz2,
• S Klug3,
• M Almonte4,
• I Guerrero4,
• M Alvarez1,
• C Velarde1,
• O Galdos1,
• M Castillo5,
• J Walboomers6,
• C Meijer6 &
• …
• E Caceres4

British Journal of Cancer volume 85, pages 966–971 (2001)Cite this article

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Abstract

We conducted a hospital-based case-control study in Peru of 198 women with histologically confirmed cervical cancer (173 squamous cell carcinomas and 25 cases of adenocarcinoma/adenosquamous carcinoma) and 196 control women. Information on risk factors was obtained by personal interview. Using PCR-based assays on exfoliated cervical cells and biopsy specimens, HPV DNA was detected in 95.3% of women with squamous cell carcinoma and in 92.0% of women with adenocarcinoma/adenosquamous carcinoma compared with 17.7% in control women. The age-adjusted odds ratio was 116.0 (95% Cl = 48.6–276.0) for squamous cell carcinoma and 51.4 (95% Cl = 11.4–232.0) for adenocarcinoma/adenosquamous carcinoma. The commonest types in women with cervical cancer were HPV 16, 18, 31, 52 and 35. The association with the various HPV types was equally strong for the two most common types (HPV 16 and 18) as for the other less common types. In addition to HPV, long-term use of oral contraceptives and smoking were associated with an increased risk. HPV is the main cause of both squamous cell carcinoma and adenocarcinoma in Peruvian women. © 2001 Cancer Research Campaign http://www.bjcancer.com

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Authors and Affiliations

1. Instituto de Enfermedades Neoplásicas ‘Dr Eduardo Cáceres Graziani', Av. Angamos Este 2520, Lima, 34, Peru
   C Santos, M Alvarez, C Velarde & O Galdos
2. International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, cédex 08, F-69372, France
   N Muñoz
3. IARC, University of Bielefeld, PO Box 100131, Bielefeld, D-33501, Germany
   S Klug
4. Maes-Heller Cancer Research Centre, Av. Angamos Este 2520, Lima, 34, Peru
   M Almonte, I Guerrero & E Caceres
5. María Auxiliadora' General Hospital, Lima, Peru
   M Castillo
6. Free University Hospital, Postbus 7057, Amsterdam, NL-1007, MB, The Netherlands
   J Walboomers & C Meijer

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1. C Santos
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2. N Muñoz
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3. S Klug
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4. M Almonte
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7. C Velarde
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8. O Galdos
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9. M Castillo
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From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Santos, C., Muñoz, N., Klug, S. et al. HPV types and cofactors causing cervical cancer in Peru.Br J Cancer 85, 966–971 (2001). https://doi.org/10.1054/bjoc.2001.1948

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• Received: 07 March 2001
• Revised: 01 June 2001
• Accepted: 05 June 2001
• Published: 02 October 2001
• Issue Date: 05 October 2001
• DOI: https://doi.org/10.1054/bjoc.2001.1948

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