Fibroblast Growth Factor 19 Serum Levels: Relation to Renal Function and Metabolic Parameters (original) (raw)
Horm Metab Res 2010; 42(3): 178-181
DOI: 10.1055/s-0029-1243249
Original Basic
© Georg Thieme Verlag KG Stuttgart · New York
M. Reiche1 [*****] , A. Bachmann1 [*****] , U. Lössner1 , M. Blüher1 , M. Stumvoll1 , M. Fasshauer1
Further Information
Publication History
received 11.08.2009
accepted 17.11.2009
Publication Date:
14 December 2009 (online)
Abstract
Fibroblast growth factor 19 (FGF19) was recently introduced as a novel metabolic regulator reversing diabetes mellitus, hepatic steatosis, hyperlipidemia, and adiposity. In the current study, we determined circulating FGF19 levels in patients on chronic hemodialysis (CD) as compared to controls with a glomerular filtration rate (GFR) above 50 ml/min. FGF19 was measured by ELISA in control (n=60) and CD (n=60) patients and correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation, in both groups. Median serum FGF19 levels were 1.5-fold higher in CD patients (266.7 μg/l) as compared to subjects with a GFR above 50 ml/min (178.1 μg/l) (p=0.001). Furthermore, fasting glucose negatively and independently predicted circulating FGF19 in controls (p<0.05). Moreover, adiponectin was a positive and C-reactive protein was a negative independent predictor of FGF19 serum concentrations in CD patients. Taken together, we have demonstrated that circulating FGF19 levels are significantly increased in end-stage renal disease. Furthermore, FGF19 is associated with a beneficial metabolic profile in both control and CD patients.
Key words
FGF19 - hemodialysis - insulin resistance - obesity
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1 These authors contributed equally to this work.