Evaluation of the Anti-Inflammatory Effect of Baicalein on Dextran Sulfate Sodium-Induced Colitis in Mice (original) (raw)

Planta Med 2002; 68(3): 268-271
DOI: 10.1055/s-2002-23143

Letter

© Georg Thieme Verlag Stuttgart · New York

• 1Department of Bioregulatory Function, University of Tokyo Graduate School of Medicine, Tokyo, Japan
• 2Department of Geriatrics, University of Tokyo Graduate School of Medicine, Tokyo, Japan

Further Information

Publication History

March 30, 2001

September 21, 2001

Publication Date:
25 March 2002 (online)

Abstract

The anti-inflammatory effect of three flavonoids from the root of Scutellaria baicalensis (baicalein, baicalin and wogonin) was evaluated in a murine model of acute experimental colitis induced by dextran sulfate sodium (DSS). Baicalein, but not baicalin or wogonin, given orally at 20 mg/kg for ten days, ameliorates all the considered inflammatory symptoms of the induced colitis, such as body weight loss, blood haemoglobin content, rectal bleeding and other histological and biochemical parameters. The effect of baicalein was similar to that of sulfasalazine, the reference drug given at 50 mg/kg.

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Tie Hong

Department of Bioregulatory Function

University of Tokyo

Graduate School of Medicine

7-3-1 Hongo, Bunkyo-Ku

Tokyo 113-8655

Japan

Email: tie-tky@umin.ac.jp

Fax: (Japan: +81) 3-3818-4754