Antihyperglycemic Effects of Paeoniflorin and 8-Debenzoylpaeoniflorin, Glucosides from the Root of Paeonia lactiflora (original) (raw)
Planta Med 1997; 63(4): 323-325
DOI: 10.1055/s-2006-957692
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York
- 1Department of Medicinal Chemistry, School of Pharmacy, Taipei Medical College, Taipei City, Taiwan 10502, Republic of China
- 2Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan 70101, Republic of China
Publication History
1996
1997
Publication Date:
04 January 2007 (online)
Abstract
Paeoniflorin and 8-debenzoylpaeoniflorin were isolated from the dried root of Paeonia lactiflora Pall. (Ranunculaceae). They produced a significant blood sugar lowering effect in streptozotocin-treated rats and had a maximum effect at 25 min after treatment. This hypoglycemic action was also observed in normoglycemic rats only at 1 mg/kg. The antihyperglycemic activity of 8-debenzoylpaeoniflorin seems lower than that of paeoniflorin. Plasma insulin was not changed in paeoniflorin-treated normoglycemic rats indicating an insulin-independent action. Also, this glucoside reduced the elevation of blood sugar in glucose challenged rats. Increase of glucose utilization by paeoniflorin can thus be considered. There are no previous data showing the hypoglycemic activity of paeoniflorin and/or 8-debenzoylpaeoniflorin in rats.
Key words
Paeonia lactiflora - Ranunculaceae - hypoglycemic effect - insulin-independent action - glucose challenge test - paeoniflorin - 8-debenzoylpaeoniflorin