Prevalence of Cardiovascular Disease and Risk Factors in the Chinese Population with Impaired Glucose Regulation: the 2007–2008 China National Diabetes and Metabolic Disorders Study (original) (raw)

Exp Clin Endocrinol Diabetes 2013; 121(06): 372-374
DOI: 10.1055/s-0033-1341520

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Authors

• Z. Yang *
  1China-Japan Friendship Hospital, Beijing
• X. Xing *
  1China-Japan Friendship Hospital, Beijing
• J. Xiao
  1China-Japan Friendship Hospital, Beijing
• J. Lu
  2Chinese People’s Liberation Army General Hospital, Beijing
• J. Weng
  3Sun Yat-sen University Third Hospital, Guangzhou
• W. Jia
  4Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai
• L. Ji
  5Peking University People’s Hospital, Beijing
• Z. Shan
  6First Affiliated Hospital, Chinese Medical University, Liaoling
• J. Liu
  7Shanxi Province People’s Hospital, Taiyuan, Shanxi
• H. Tian
  8West China Hospital, Sichuan University, Chengdu, Sichuan
• Q. Ji
  9Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi
• D. Zhu
  10Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu
• J. Ge
  11Xinjiang Uygur Autonomous Region’s Hospital, Urmqi, Xinjiang
• L. Lin
  12Fujian Provincial Hospital, Fuzhou, Fujiang
• L. Chen
  13Qilu Hospital, Qilu Hospital of Shandong University, Jinan, Shandong
• X. Guo
  14Peking University First Hospital, Beijing
• Z. Zhao
  15Henan Province People’s Hospital, Zhengzhou, Henan
• Q. Li
  16Second Affiliated Hospital of Harbin Medical University, Harbin, ­Heilongjiang
• Z. Zhou
  17Xiangya Second Hospital, Changsha, Hunan
• W. Yang
  1China-Japan Friendship Hospital, Beijing and the China National Diabetes and Metabolic Disorders Study Group

Further Information

Publication History

received 10 December 2012
first decision 18 March 2013

accepted 20 March 2013

Publication Date:
24 April 2013 (online)

Abstract

Aims:

Cardiovascular disease (CVD) is one of the most common chronic diseases in China. This aim of this study is to determine the prevalence of CVDs and risk factors in Chinese impaired glucose regulation subjects.

Methods:

We used a multistage, stratified sampling method to select subjects from the general Chinese population aged 20 years and older. Subjects underwent an oral glucose tolerance test to identify normal glucose tolerance (NGT) and impaired glucose regulation including isolated impaired fasting glucose (i-IFG), impaired glucose tolerance (i-IGT), and combined IFG/IGT and diabetic mellitus (DM). A logistic regression analysis was performed to examine the association between glucose abnormalities and CVD events.

Results:

We identified that 34 293 subjects had NGT, 1 469 i-IFG, 4 571 i-IGT, 957 IFG/IGT and 4 949 DM. The age-sex standardized prevalence rate of cardiovascular disease was 1.06% (95% CI 0.87–1.28), 1.79% (95% CI 1.37–2.33) and 3.83% (95% CI 2.79–5.24) in NGT, impaired glucose regulation and DM, respectively. Among impaired glucose subjects, prevalence of defined CVD risk factors (smoking, overweight, obesity, hypertension and dyslipidemia) was 29.52% (95% CI: 27.8–31.21), 36.25% (95% CI: 34.29–38.26), 10.05% (95% CI: 8.86–11.37), 36.43% (95% CI: 34.53–38.36) and 69.96% (95% CI: 67.87–71.98), respectively. Compared to 1 risk factor, the odds ratios (ORs) of CVDs with 2, 3 or 4 risk factors were 1.94 (95% CI: 0.74–5.09), 2.76 (95% CI: 1.06–7.21) and 5.84 (95% CI: 1.68–20.26), respectively. Additionally, compared to i-IFGs, ORs of CVDs with i-IGT and IFG/IGT were 2.88 (95%CI 1.36–6.01) and 2.12 (95% CI 0.83–5.44), respectively.

Conclusion:

The prevalence of cardiovascular risk factors was high in the Chinese impaired glucose regulation population. The postprandial hyperglycemia is more associated with CVD than isolated fasting hyperglycemia.

Key words

diabetes - cardiovascular risk ­management - metabolic features

*

* These authors contributed equally to this work.

• References

• 1 Khor GL. Cardiovascular epidemiology in the Asia-Pacific region. Asia Pacific journal of clinical nutrition 2001; 10: 76-80
• 2 Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA: the journal of the American Medical Association. 1979. 241. 2035-2038
• 3 Yang W, Lu J, Weng J et al. Prevalence of diabetes among men and women in China. The New England journal of medicine 2010; 362: 1090-1101
• 4 Pan XR, Yang WY, Li GW et al. Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group. Diabetes care 1997; 20: 1664-1669
• 5 Yang ZJ, Liu J, Ge JP et al. Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007–2008 China National Diabetes and Metabolic Disorders Study. European heart journal 2012; 33: 213-220
• 6 Wu Z, Yao C, Zhao D et al. Sino-MONICA project: a collaborative study on trends and determinants in cardiovascular diseases in China, Part i: morbidity and mortality monitoring. Circulation 2001; 103: 462-468
• 7 Meigs JB, Nathan DM, D’Agostino Sr RB et al. Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diabetes care 2002; 25: 1845-1850
• 8 Tominaga M, Eguchi H, Manaka H et al. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes care 1999; 22: 920-924