Sonochemistry as a General Procedure for the Synthesis of Coumarins­, Including Multigram Synthesis (original) (raw)

Synthesis 2017; 49(12): 2677-2682
DOI: 10.1055/s-0036-1590201

© Georg Thieme Verlag Stuttgart · New York

Authors

• Ligia S. da Silveira Pinto
  aUniversidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, CP 68563, 21945-970 Rio de Janeiro, Brazil
• Marcus V. N. de Souza*
  aUniversidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, CP 68563, 21945-970 Rio de Janeiro, Brazil
  bFioCruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far-Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 Rio de Janeiro, Brazil Email: marcos_souza@far.fiocruz.br

Further Information

Publication History

Received: 13 December 2016

Accepted after revision: 28 February 2017

Publication Date:
24 March 2017 (online)

Abstract

This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.

Key words

coumarins - sonochemistry - synthesis - multigram scale - smaller scale

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