Increased Activity of Glycerol 3-phosphate Dehydrogenase and Other Lipogenic Enzymes in Human Bladder Cancer (original) (raw)

Horm Metab Res 2003; 35(10): 565-569
DOI: 10.1055/s-2003-43500

Original Basic

J. Turyn1 , B. Schlichtholz1 , A. Dettlaff-Pokora1 , M. Presler1 , E. Goyke1 , M. Matuszewski2 , Z. Kmieć3 , K. Krajka2 , J. Swierczynski1

1Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
2Department of Urology, Medical University of Gdansk, Gdansk, Poland
3Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland

Further Information

Publication History

Received 3 February 2003

Accepted after second revision 14 July 2003

Publication Date:
07 November 2003 (online)

Abstract

Common molecular changes in cancer cells are high carbon flux through the glycolytic pathway and overexpression of fatty acid synthase, a key lipogenic enzyme. Since glycerol 3-phosphate dehydrogenase creates a link between carbohydrates and the lipid metabolism, we have investigated the activity of glycerol 3-phosphate dehydrogenase and various lipogenic enzymes in human bladder cancer.

The data presented in this paper indicate that glycerol 3-phosphate dehydrogenase activity in human bladder cancer is significantly higher compared to adjacent non-neoplastic tissue, serving as normal control bladder tissue. Increased glycerol 3-phosphate dehydrogenase activity is accompanied by increased enzyme activity, either directly (fatty acid synthase) or indirectly (through ATP-citrate lyase, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and citrate synthase) involved in fatty acid synthesis. Coordinated upregulation of glycerol 3-phosphate dehydrogenase and lipogenic enzymes activities in human bladder cancer suggests that glycerol 3-phosphate dehydrogenase supplies glycerol 3-phosphate for lipid biosynthesis.

Key words

Glycerol 3-phosphate dehydrogenase - Lipogenic enzymes - Bladder cancer

References

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J. Swierczynski, M. D., Ph. D.

Department of Biochemistry · Medical University of Gdansk

ul. Debinki 1 · 80-211 Gdansk · Poland

Fax: +48 (58) 349 14 65

Email: juls@amg.gda.pl