New Polyacetylenes, DGAT Inhibitors from the Roots of Panax ginseng (original) (raw)
Planta Med 2004; 70(3): 197-200
DOI: 10.1055/s-2004-815534
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York
Seung Woong Lee1 , Koanhoi Kim1 , Mun-Chual Rho1 , Mi Yeon Chung1 , Young Ho Kim2 , Sangku Lee1 , Hyun Sun Lee1 , Young Kook Kim1
- 1Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
- 2College of Pharmacy, Chungnam National University, Taejon, Korea
This research was supported by grants from Plant Diversity Research Center of 21st Century Frontier Research Program and KRIBB Research Initiative Program funded by the Ministry of Science and Technology of the Korean government
Publication History
Received: August 15, 2003
Accepted: November 22, 2003
Publication Date:
23 March 2004 (online)
Abstract
The petroleum ether extract of Panax ginseng showed a significant inhibition of the diacylglycerol acyltransferase (DGAT) enzyme from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of two new polyacetylenic compounds, (9_R_,10_S_)-epoxyheptadecan-4,6-diyn-3-one (1) and 1-methoxy-(9_R_,10_S_)-epoxyheptadecan-4,6-diyn-3-one (2). Their chemical structures were elucidated on the basis of spectroscopic evidence and asymmetric synthesis. IC50 values of 9 μg/mL (1) and 32 μg/mL (2) were obtained.
Key words
Panax ginseng - Araliaceae - diacylglycerol acyltransferase (DGAT) - polyacetylenes - structure elucidation
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Hyun Sun Lee, Ph. D.
Laboratory of Lipid Metabolism
Korea Research Institute of Bioscience and Biotechnology
P.O. Box 115
Yusong
Taejon 305 - 333
Korea
Phone: +82-42-860-4314
Fax: +82-42-861-2675
Email: leehs@kribb.re.kr