Sequence effects on the forced translocation of heteropolymers through a small channel (original) (raw)
Research Article| May 02 2008
Department of Physics,
University of Ottawa
, 150 Louis-Pasteur, Ottawa, Ontario K1N 6N5,
Canada
Search for other works by this author on:
Department of Physics,
University of Ottawa
, 150 Louis-Pasteur, Ottawa, Ontario K1N 6N5,
Canada
Search for other works by this author on:
Electronic mail: michel_gauthier@sfu.ca.
Electronic mail: gary.slater@uttawa.ca.
J. Chem. Phys. 128, 175103 (2008)
By using a recently developed Monte Carlo algorithm and an exact numerical method, we calculate the translocation probability and the average translocation time for charged heterogeneous polymers driven through a nanopore by an external electric field. The heteropolymer chains are composed of two types of monomers (A and B) which differ only in terms of their electric charge. We present an exhaustive study of chains composed of eight monomers by calculating the average translocation time associated with the 256 possible arrangements for various ratios of the monomer charges (λA∕λB) and electric field intensities E. We find that each sequence leads to a unique value of the translocation probability and time. We also show that the distribution of translocation times is strongly dependent on the two forces felt by the monomers (∼λAE and ∼λBE). Finally, we present results that highlight the effect of having repetitive patterns by studying the translocation times of various block copolymer structures for a very long chain composed of N=218 monomers (all with the same number of A and B monomers).
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© 2008 American Institute of Physics.
2008
American Institute of Physics
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