Rapid chylomicron appearance following sequential meals: effects of second meal composition | British Journal of Nutrition | Cambridge Core (original) (raw)

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentrations following successive fat-rich meals. An earlier study has shown that the triacylglycerol in this early peak originates from a previous meal. The present study was performed to investigate the effects of different second meals on the plasma triacylglycerol response. Six healthy subjects were studied on four occasions each. At 5 h following a fat-rich breakfast they ingested one of the following in a balanced design: a fat-rich meal, a low-fat meal, water or nothing by mouth. Blood samples were taken for 2.5 h following the second meal. An early peak in chylomicron and plasma triacylglycerol concentrations was seen following both low-fat and fat-rich second meals but not following water. During studies investigating postprandial lipaemia, further meals must be avoided, even if they contain no fat, although water may be allowed.

Type

Human and Clinical Nutrition

References

Cohn, JS, McNamara, JR, Cohn, SD, Ordovas, JM & Schaefer, EJ (1988) Postprandial plasma lipoprotein changes in human subjects of different ages. Journal of Lipid Research 29, 469–479.CrossRef Google Scholar PubMed

Cohn, JS, McNamara, JR, Krasinski, SD, Russell, RM & Schaefer, EJ (1989) Role of triglyceride-rich lipoproteins from the liver and intestine in the etiology of postprandial peaks in plasma triglyceride concentration. Metabolism 38, 484–490.CrossRef Google Scholar PubMed

Coppack, SW, Fisher, RM, Gibbons, GF, Humphreys, SM, McDonough, MJ, Potts, JL & Frayn, KN (1990) Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clinical Science 79, 339–348.CrossRef Google Scholar PubMed

Coppack, SW, Frayn, KN & Humphreys, SM (1989) Plasma triacylglycerol extraction in human adipose tissue in vivo: effects of glucose ingestion and insulin infusion. European Journal of Clinical Nutrition 43, 493–496.Google Scholar PubMed

Fielding, BA, Callow, J, Owen, RM, Samra, JS, Matthews, DR & Frayn, KN (1996) Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals. American Journal of Clinical Nutrition 63, 36–41.CrossRef Google Scholar PubMed

Griffiths, JA, Humphreys, SM, Clark, ML, Fielding, BA & Frayn, KN (1994) Immediate metabolic availability of dietary fat in combination with carbohydrate. American Journal of Clinical Nutrition 59, 53–59.CrossRef Google Scholar PubMed

Holland, BA, Welch, AA, Unwin, ID, Buss, DH, Paul, AA & Southgate, DAT (1991). McCance and Widdowson's The Composition of Foods, 5th ed. Cambridge: Royal Society of Chemistry.Google Scholar

Kalogeris, T, Monroe, F, Demichelle, S & Tso, P (1996) Intestinal synthesis and lymphatic secretion of apolipoprotein A-IV vary with chain length of intestinally infused fatty acids in rats. Journal of Nutrition 126, 2720–2729.Google Scholar PubMed

Mattes, RD (1996) Oral fat exposure alters postprandial lipid metabolism in humans. American Journal of Clinical Nutrition 63, 911–917.Google Scholar PubMed

Mendeloff, AI (1954) The effects of eating and of sham feeding upon the absorption of vitamin A palmitate in man. Journal of Clinical Investigation 33, 1015–1021.CrossRef Google Scholar PubMed

Patsch, JR, Miesenböck, G, Hopferwieser, T, Mühlberger, V, Knapp, E, Dunn, JK, Gotto, AMJ & Patsch, W (1992) Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arteriosclerosis and Thrombosis 12, 1336–1345.CrossRef Google Scholar PubMed

Peel, AS, Zampelas, A, Williams, CM & Gould, BJ (1993) A novel antiserum specific to apolipoprotein B-48: application in the investigation of postprandial lipidaemia in humans. Clinical Science 85, 521–524.CrossRef Google Scholar PubMed

Williams, CM, Moore, F, Morgan, L & Wright, J (1992) Effects of _n_-3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects. British Journal of Nutrition 68, 655–666.CrossRef Google Scholar PubMed