Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered | British Journal of Nutrition | Cambridge Core (original) (raw)

References

Acheson, KJ, Jéquier, E & Wahren, J (1983) Influence of β-adrenergic blockade on glucose-induced thermogenesis in man. Journal of Clinical Investigation 72, 981–986.CrossRefGoogle ScholarPubMed

Arch, JRS, Ainsworth, AT, Cawthorne, MA, Piercy, V, Sennit, MV, Thody, VE, Wilson, C & Wilson, S (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309, 163–165.CrossRefGoogle ScholarPubMed

Ardawi, MS, Majzoub, MF, Masoud, IM & Newsholme, EA (1989) Enzymatic and metabolic adaptations in the gastrocnemius, plantaris and soleus muscles of hypocaloric rats. Biochemical Journal 264, 219–225.Google Scholar

Argyropoulos, G, Brown, AM, Willi, SM, Zhu, J, He, Y, Reitman, M, Spruill, SM & Garvey, WT (1998) Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. Journal of Clinical Investigation 102, 1345–1351.CrossRefGoogle ScholarPubMed

Arsenijevic, D, Onuma, H, Pecqueur, C, Raimbault, S, Manning, BS, Miroux, B, Couplan, E, Alves-Guerra, MC, Goubern, M, Surwit, R, Bouillaud, F, Richard, D, Collins, S & Ricquier, D et al. (2000) Disruption of the uncoupling-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nature and Genetics 26, 435–439.CrossRefGoogle Scholar

Astrup, A, MacDonald, IA, (1998) Sympathoadrenal system and metabolism. In Handbook of Obesity, pp. 491–511.[Bray, GA, Bouchard, C and James, WPT, editors]. New York, NY: Marcel Dekker Inc.Google Scholar

Astrup, A, Toubro, S, Dalgaard, LT, Urhammer, SA, Sorensen, TIA & Pedersen, O (1999) Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation. International Journal of Obesity 23, 1030–1034.CrossRefGoogle Scholar

Berry, MN, Clark, DG, Grivell, AR & Wallace, PG (1985) The contribution of hepatic metabolism to diet-induced thermogenesis. Metabolism 34, 141–147.Google Scholar

Berson, A, De Beco, V, Letteron, P, Robin, MA, Moreau, C, El Kahwaji, J, Verthier, N, Feldmann, G, Fromenty, B & Pessayre, D (1998) Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology 114, 764–774.Google Scholar

Boss, O, Samec, S, Paoloni-Giacobino, A, Rossier, C, Dulloo, AG, Seydoux, J, Muzzin, P & Giacobino, JP (1997) Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression. FEBS Letters 408, 39–42.CrossRefGoogle ScholarPubMed

Boss, O, Hagen, T & Lowell, BB (2000) Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes 49, 143–156.CrossRefGoogle ScholarPubMed

Brand, M, Brindle, KM, Buckingham, JA, Harper, JA, Rolfe, DFS & Stuart, JA (1999) The significance and mechanism of mitochondrial proton conductance. International Journal of Obesity 23, S4–S11.CrossRefGoogle ScholarPubMed

Brun, S, Carmona, MC, Mampel, T, Vinas, O, Giralt, M, Iglesias, R & Villarroya, F (1999) Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids. FEBS Letters 453, 205–209.CrossRefGoogle ScholarPubMed

Cadenas, S, Buckingham, JA, Samec, S, Seydoux, J, Din, N, Dulloo, AG & Brand, MD (1999) UCP2 and UCP3 rise in starved rat skeletal muscle but not mitochondrial proton conductance is unchanged. FEBS Letters 462, 257–260.CrossRefGoogle Scholar

Clapham, JC, Arch, JR, Chapman, A, Haynes, A, Lister, C, Moore, GBT, Piercy, V, Carter, SA, Lehner, I, Smith, SA, Beeley, LJ, Godden, RJ, Herrity, N, Skehel, M & Changani, KK (2000) Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406, 415–418.CrossRefGoogle ScholarPubMed

Cline, GW, Vidal-Puig, AJ, Dufour, S, Cadman, KS, Lowell, BB & Shulman, GI (2001) In vivo effects of uncoupling protein 3 gene disruption on mitochondrial metabolism. Journal of Biological Chemistry 276, 20240–20244.Google Scholar

Cortez-Pinto, H, Lin, HZ, Yang, SQ, Da Costa, SO & Diehl, AM (1999) Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. Gastroenterology 116, 1184–1193.CrossRefGoogle ScholarPubMed

Denjean, F, Lachuer, J, Geloen, A, Cohen-Adad, F, Moulin, C, Barre, H & Duchamp, C (1999) Differential regulation of uncoupling protein-1, -2 and -3 gene expression by sympathetic innervation in brown adipose tissue of thermoneutral or cold-exposed rats. FEBS Letters 444, 181–185.CrossRefGoogle ScholarPubMed

Diano, S, Urbanski, HF, Horvath, B, Bechmann, I, Kagiya, A, Nemeth, G, Naftolin, F, Warden, CH & Horvath, TL (2000) Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary. Endocrinology 141, 4226–4238.CrossRefGoogle Scholar

Dulloo, AG (1999) UCP2 and UCP3: candidate genes for thermogenesis or lipid handling. Obesity Matters 2, 5–8.Google Scholar

Dulloo, AG & Girardier, L (1990) Adaptive changes in energy expenditure during refeeding following low calorie intake: evidence for a specific metabolic component favoring fat storage. American Journal of Clinical Nutrition 52, 415–420.CrossRefGoogle ScholarPubMed

Dulloo, AG & Girardier, L (1992) Influence of dietary composition on energy expenditure during recovery of body weight in the rat: Implications for catch-up growth and obesity relapse. Metabolism 41, 1336–1342.CrossRefGoogle ScholarPubMed

Dulloo, AG & Jacquet, J (1998) Adaptive reduction in basal metabolic rate in response to food deprivation in humans: a role for feedback signals from fat stores. American Journal of Clinical Nutrition 68, 599–606.CrossRefGoogle ScholarPubMed

Dulloo, AG & Jacquet, J (1999) Low-protein overfeeding: a tool to unmask susceptibility to obesity in humans. International Journal of Obesity 23, 1118–1121.Google Scholar

Dulloo, AG & Jacquet, J (2001) An adipose-specific control of thermogenesis in body weight regulation. International Journal of Obesity (In the Press).Google Scholar

Dulloo, AG & Miller, DS (1984) Energy balance following sympathetic denervation of brown adipose tissue. Canadian Journal of Physiology and Pharmacology 62, 235–240.CrossRefGoogle ScholarPubMed

Dulloo, AG & Miller, DS (1987) Obesity: a disorder of the sympathetic nervous system. World Reviews in Nutrition and Dietetics 50, 1–56.CrossRefGoogle ScholarPubMed

Dulloo, AG & Samec, S (2000) Uncoupling proteins: Do they have a role in weight regulation? News in Physiological Science 15, 313–318.Google ScholarPubMed

Dulloo, AG, Seydoux, J & Girardier, L (1995) Dissociation of enhanced efficiency of fat deposition during weight recovery from sympathetic control of thermogenesis. American Journal of Physiology 269, R365–R369.Google ScholarPubMed

Dulloo, AG, Jacquet, J & Girardier, L (1996) Autoregulation of body composition during weight recovery in humans: the Minnesota Experiment revisited. International Journal of Obesity 20, 393–405.Google ScholarPubMed

Enerbäck, S, Jacobsson, A, Simpson, EM, Guerra, C, Yamashita, H, Harper, ME & Kozak, LP (1997) Mice lacking mitochondrial uncoupling protein are cold sensitive but not obese. Nature 387, 90–94.CrossRefGoogle Scholar

Fleury, C, Neverova, M, Collins, S, Raimbault, S, Champigny, O, Levi-Meyrueis, C, Bouillaud, F, Seldin, MF, Surwit, RS, Ricquier, D & Warden, CH (1997) Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinaemia. Nature and Genetics 15, 269–272.Google Scholar

Garlid, KD, Orosz, DE, Modriansky, M, Vassanelli, S & Jezek, P (1996) On the mechanism of fatty acid-induced proton transport by mitochondrial protein. Journal of Biological Chemistry 271, 2615–2620.CrossRefGoogle Scholar

Girardier, L (1983) Brown fat: an energy dissipating tissue. In Mammalian Thermogenesis, pp. 51–97 [Girardier, L and Stock, MJ, editors]. London: Chapman & Hall.CrossRefGoogle Scholar

Gong, DW, He, Y, Karas, M & Reitman, ML (1997) Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β-adrenergic agonists, and leptin. Journal of Biological Chemistry 272, 24129–24132.Google Scholar

Gong, DW, Monemdjou, S, Gavrilova, O, Leon, LR, Marcus-Samuels, B, Chou, CJ, Everett, C, Kozak, LP, Li, C, Deng, C, Harper, ME & Reitman, ML (2000) Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. Journal of Biological Chemistry 275, 16251–16257.CrossRefGoogle ScholarPubMed

Harper, ME & Himms-Hagen, J (2001) Mitochondrial efficiency: lessons learned from transgenic mice. Biochimica et Biophysica Acta 1504, 159–172.CrossRefGoogle ScholarPubMed

Hildebrandt, AL & Neufer, DL (2000) Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle. American Journal of Physiology 278, E1078–E1086.Google ScholarPubMed

Himms-Hagen, J & Harper, ME (2001) Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Proceedings of the Society for Experimental Biology and Medicine 226, 78–84.CrossRefGoogle ScholarPubMed

Hjeltnes, N, Fernström, M, Zierath, JR & Krook, A (1999) Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects. Diabetologia 42, 826–830.CrossRefGoogle ScholarPubMed

Iossa, S, Lionetti, L, Mollica, MP, Crescenzo, R, Barletta, A & Liverini, G (2000) Effect of long-term high-fat feeding on energy balance and liver oxidative activity in rats. British Journal of Nutrition 84, 377–385.Google Scholar

Jansky, L (1995) Humoral thermogenesis and its role in maintaining energy balance. Physiology Review 75, 237–259.CrossRefGoogle ScholarPubMed

Jezek, P, Engstova, H, Zackova, M, Vercesi, AE, Costa, AD, Arruda, P & Garlid, KD (1998) Fatty acid cycling mechanism and mitochondrial uncoupling proteins. Biochimica et Biophysica Acta 1365, 319–327.Google Scholar

Jucker, BM, Ren, J, Dufour, S, Cao, X, Previs, SF, Cadman, KS & Schulman, GI (2000) 13C/31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats: relationship with uncoupling protein 3 expression. Journal of Biological Chemistry 275, 39279–39286.Google Scholar

Keys, A, Brozek, J, Henschel, A, Mickelson, O & Taylor, HL (1950) The Biology of Human Starvation.Minneapolis, MN: University of Minnesota Press.CrossRefGoogle Scholar

Kozak, LP & Harper, ME (2000) Mitochondrial uncoupling proteins in energy expenditure. Annual Review of Nutrition 20, 339–363.CrossRefGoogle ScholarPubMed

Landsberg, L, Saville, ME & Young, JB (1984) The sympathoadrenal system and regulation of thermogenesis. American Journal of Physiology 247, E181–E189.Google ScholarPubMed

Lavoisier, AL & Laplace, PS (1780) Mémoire sur la Chaleur (Review on Heat Production); Oeuvres de Lavoisier, Paris: L'Academie Royale.Google Scholar

Lean, ME, James, WP, Jennings, G & Trayhurn, P (1986) Brown adipose tissue in patients with phaeochromocytoma. International Journal of Obesity 10, 219–227.Google ScholarPubMed

Leibel, RL, Rosenbaum, M & Hirsch, J (1995) Changes in energy expenditure resulting from altered body weight. New England Journal of Medicine 332, 621–628.Google Scholar

Levine, JA, Eberhardt, NL & Jensen, MD (1999) Role of non-exercise activity thermogenesis in resistance to fat gain in humans. Science 283, 212–214.CrossRefGoogle Scholar

Luke, A & Schoeller, D (1992) Basal metabolic rate, fat-free-mass, and body cell mass during energy restriction. Metabolism 41, 450–456.Google Scholar

Ma, SWY & Foster, DO (1986) Starvation-induced changes in metabolic rate, blood flow, and regional energy expenditure in rats. Canadian Journal of Physiology and Pharmacology 64, 1252–1258.Google Scholar

Ma, SWY, Nadeau, BE & Foster, DO (1987) Evidence for liver as the major site of the diet-induced thermogenesis of rats fed a cafeteria-diet. Canadian Journal of Physiology and Pharmacology 65, 1802–1804.CrossRefGoogle ScholarPubMed

Mao, W, Yu, XX, Zhong, A, Li, W, Brush, J, Sherwood, SW, Adams, SH & Pan, G (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Letters 443, 326–330.CrossRefGoogle ScholarPubMed

Matthias, A, Kerstin, BE, Ohlson, BE, Fredriksson, JM, Jacobsson, A, Nedergaard, J & Cannon, B (2000) Thermogenic responses in brown fat cells are fully UCP1-dependent. Journal of Biological Chemistry 33, 25073–25081.CrossRefGoogle Scholar

Miller, DS & Mumford, P (1967) Gluttony 1. An experimental study of overeating low- or high-protein diets. American Journal of Clinical Nutrition 20, 1212–1222.Google Scholar

Miller, DS, Mumford, P & Stock, MJ (1967) Gluttony 2. Thermogenesis in overeating man. American Journal of Clinical Nutrition 20, 1223–1229.CrossRefGoogle ScholarPubMed

Millet, L, Vidal, H, Andreelli, F, Larrouy, D, Riou, JP, Ricquier, D, Laville, M & Langin, D (1997) Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. Journal of Clinical Investigation 100, 2665–2670.CrossRefGoogle ScholarPubMed

Monemdjou, S, Hofmann, WE, Kozak, LP & Harper, ME (2000) Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice. American Journal of Physiology E941–E946.Google ScholarPubMed

Muoio, D, Vidal-Puig, AJ, Grujic, D, Koves, T, Dohm, GL, Lowell, B, Cortright, R, LGirardier, & MJStock, (2000) Fuel metabolism in muscles from UCP-3 knock-out mice. Keystone Symposium on Molecular Control of Adipogenesis and Obesity, Silverthorne, Colorado, USA, p. 143.Google Scholar

Nagase, I, Yoshida, T, Kumamoto, K, Umekawa, T, Sakane, N, Nikami, H, Kawada, T & Saito, M (1996) Expression of uncoupling protein in skeletal muscle and white adipose tissue of obese mice treated with thermogenic β3-adrenergic agonist. Journal of Clinical Investigation 97, 2898–2904.CrossRefGoogle Scholar

Nedergaard, J & Cannon, B (1992) The uncoupling protein thermogenin and mitochondrial thermogenesis. In New Comprehensive Biochemistry (Molecular Mechanisms in Bioenergetics) pp. 385–419 [Ernster, L, editor]. Amsterdam: Elsevier Science Publishers.Google Scholar

Négre-Salvayre, A, Hirtz, C, Carrera, G, Cazenave, R, Troly, M, Salvayre, R, Penicaud, L & Casteilla, L (1997) A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB Journal 11, 809–815.CrossRefGoogle ScholarPubMed

Nicholls, DG & Rial, E (1999) A history of the first uncoupling protein, UCP1. Journal of Bioenergetics and Biomembranes 31, 399–406.CrossRefGoogle ScholarPubMed

Pastore, D, Fratianni, A, Di Pede, S & Passarella, S (2000) Effects of fatty acids, nucleotides and reactive oxygen species on durum wheat mitochondria. FEBS Letters 470, 88–92.Google Scholar

Peachey, T, French, RR & York, DA (1988) Regulation of GDP binding and uncoupling protein concentration in brown adipose tissue mitochondria. Biochemistry Journal 249, 451–457.Google Scholar

Pecqueur, C, Alves-Guerra, MC, Gelly, C, Lévi-Meyrueis, C, Couplan, E, Collins, S, Ricquier, D, Bouillaud, F & Miroux, B (2001a) Uncoupling protein 2: in vivo distribution, induction upon oxidative stress and evidence for translational regulation. Journal of Biological Chemistry 276, 8705–8712.CrossRefGoogle ScholarPubMed

Pecqueur, C, Couplan, E, Bouillaud, F & Ricquier, D (2001b) Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis. Journal of Molecular Medicine 79, 48–56.Google Scholar

Raimbault, S, Dridi, S, Denjean, F, Lachuer, J, Couplan, E, Bouillaud, F, Bordas, A, Duchamp, C, Taouis, M & Ricquier, D (2001) An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds. Biochemistry Journal 353, 441–444.CrossRefGoogle ScholarPubMed

Rashid, A, Wu, TC, Huang, CC, Chen, CH, Lin, HZ, Yang, SQ, Lee, FY & Diehl, AM (1999) Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 29, 1131–1138.CrossRefGoogle ScholarPubMed

Richard, D, Huang, Q, Sanchis, D & Ricquier, D (1999) Brain distribution of UCP2 mRNA: in situ hybridization histochemistry studies. International Journal of Obesity 23 Suppl. 6, S53–S55.Google Scholar

Ricquier, D & (1999) The family of uncoupling proteins and its role in energy expenditure and body weight control. In Progress in Obesity Research: 8, pp. 381–385 [Guy-Grand, B and Ailhaud, G, editors]. London: John Libbey.Google Scholar

Ricquier, D & Bouillaud, F (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochemical Journal 345, 161–179.Google Scholar

Rolfe, DF & Brand, MD (1996) Contribution of mitochondrial proton leak to skeletal muscle respiration and to standard metabolic rate. American Journal of Physiology 271, 1380–1389.CrossRefGoogle ScholarPubMed

Rothwell, NJ & Stock, MJ (1979) A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31–35.CrossRefGoogle ScholarPubMed

Samec, S, Seydoux, J & Dulloo, AG (1998a) Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB Journal 12, 715–724.Google Scholar

Samec, S, Seydoux, J & Dulloo, AG (1998b) Interorgan signaling between brown adipose tissue metabolism and skeletal muscle uncoupling protein homologs: Is there a role for circulating free fatty acids? Diabetes 47, 1693–1698.CrossRefGoogle Scholar

Samec, S, Seydoux, J & Dulloo, AG (1999) Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition. A link with insulin resistance. Diabetes 48, 436–441.CrossRefGoogle ScholarPubMed

Samec, S, Seydoux, J & Dulloo, AG (2000a) Further dissociations between skeletal muscle UCPs gene expressions and dietary regulation of thermogenesis. International Journal of Obesity 24 Suppl. 1, S61.Google Scholar

Samec, S, Seydoux, J & Dulloo, AG (2000b) Downregulation of skeletal muscle UCP-3 gene expression during refeeding is prevented by cold exposure. European Journal of Physiology 439, 723–729.Google Scholar

Samec, S, Seydoux, J & Dulloo, AG (2001) Skeletal muscle heterogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3 and key regulators of lipid oxidation. International Journal of Obesity 25 Suppl. 2, S49.Google Scholar

Sanchis, D, Fleury, C, Chomiki, N, Goubern, M, Huang, Q, Neverova, M, Gregoire, F, Easlick, J, Raimbault, S, Levi-Meyrueis, C, Miroux, B, Collins, S, Seldin, M, Richard, D, Warden, C, Bouillaud, F & Ricquier, D (1998) BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. Journal of Biological Chemistry 273, 34611–34615.CrossRefGoogle ScholarPubMed

Schrauwen, P, Hoppeler, H, Billeter, R, Bakker, AHF & Pendergast, DR (2001) Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet. International Journal of Obesity 25, 449–456.Google Scholar

Simoneau, JA, Kelley, DE, Neverova, M & Warden, CH (1998) Overexpression of muscle uncoupling protein-2 in human obesity associated with reduced muscle lipid utilization. FASEB Journal 12, 1739–1745.CrossRefGoogle ScholarPubMed

Skulachev, VP (1996) Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Quarterly Review of Biophysics 29, 169–202.Google Scholar

Skulachev, VP (1998) Uncoupling: new approaches to an old problem of bioenergetics. Biochimica et Biophysica Acta 1363, 100–124.CrossRefGoogle Scholar

Stock, MJ (1999a) Gluttony and thermogenesis revisited. International Journal of Obesity 23, 1105–1117.Google Scholar

Stock, MJ (1999b) Molecular and genetic aspects of the UCPs: view from the chair. International Journal of Obesity 23 Suppl. 6, S51–S52.Google Scholar

Steppan, CM, Bailey, ST, Bhat, S, Brown, EJ, Banerjee, RR, Wright, CM, Patel, HR, Ahima, RS & Lazar, MA (2001a) The hormone resistin links obesity to diabetes. Nature 409, 307–312.Google Scholar

Stuart, JA, Cadenas, S, Jekabsons, MB, Roussel, D & Brand, MD (2001b) Mitochondrial proton leak and the uncoupling protein 1 homologues. Biochimca et Biophysica Acta 1504, 144–158.Google Scholar

Stuart, JA, Harper, JA, Brindle, KM, Jekabsons, MB & Brand, MD (2001) Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. Journal of Biological Chemistry 276, 18633–18639.CrossRefGoogle Scholar

Trayhurn, P (1990) Energy expenditure and thermogenesis: animal studies on brown adipose tissue. International Journal of Obesity 14 Suppl. 1, 17–26.Google Scholar

Van der Lee, KAJM, Willemsen, PHM, Van der Vusse, GJ & Van Bilsen, M (2000) Effects of fatty acids on uncoupling protein-2 expression in the rat heart. FASEB Journal 14, 495–502.Google Scholar

Vianna, CR, Hagen, T, Zhang, CY, Bachman, E, Boss, O, Gereben, B, Moriscot, AS, Lowell, BB, Bicudo, JE & Bianco, AC (2001) Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Physiology and Genomics 5, 137–145.CrossRefGoogle ScholarPubMed

Vidal-Puig, AJ, Solanes, G, Grujic, D, Flier, JS & Lowell, BB (1997) An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochemistry and Biophysics Research Communications 235, 79–82.CrossRefGoogle ScholarPubMed

Vidal-Puig, AJ, Grujic, D, Zhang, CY, Hagen, T, Boss, O, Ido, Y, Szczepanik, A, Wade, J, Mootha, V, Cortright, R, Muoio, DM & Lowell, BB (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. Journal of Biological Chemistry 275, 16258–16266.CrossRefGoogle ScholarPubMed

Weigle, DS, Selfridge, LE, Schwartz, MW, Seeley, RJ, Cummings, DE, Havel, PJ, Kuijper, JL and Bertrande Rio, H (1998) Elevated free fatty acids induce uncoupling protein 3 expression in muscle. A potential explanation for the effect of fasting. Diabetes 47, 298–302.Google Scholar

Weyer, C, Gauthier, JF & Danforth, E (1999) Development of beta 3-adrenoceptor agonists for the treatment of obesity and diabetes - an update. Diabetes Metabolism 25, 11–21.Google Scholar

Weyer, C, Walford, RL, Harper, IT, Milner, M, MacCallum, T, Tataranni, PA & Ravussin, E (2000) Energy metabolism after 2 yr of energy restriction: the Biosphere 2 experiment. American Journal of Clinical Nutrition 72, 946–953.CrossRefGoogle Scholar

Williams, RS & Wagner, PD (2000) Transgenic animals in integrative biology: approaches and interpretations of outcome. Journal of Applied Physiology 88, 1119–1126.CrossRefGoogle ScholarPubMed

Yu, XX, Mao, W, Zhong, A, Schow, P, Brush, J, Sherwood, SS, Adams, SH & Pan, G (2000) Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB Journal 14, 1611–1618.CrossRefGoogle ScholarPubMed