Is LRIG1 a Tumour Suppressor Gene at Chromosome 3p14.3? (original) (raw)

Authors

• Ha˚kan Hedman From the Department of Radiation Sciences and Oncology, University Hospital, Umea , Sweden
• Jonas Nilsson From the Department of Radiation Sciences and Oncology, University Hospital, Umea , Sweden
• Dongsheng Guo From the Department of Radiation Sciences and Oncology, University Hospital, Umea , Sweden
• Roger Henriksson From the Department of Radiation Sciences and Oncology, University Hospital, Umea , Sweden

DOI:

https://doi.org/10.1080/028418602760169398

Abstract

The LRIG1 gene (formerly LIG-1 ), recently cloned by us, displays structural similarities to the Drosophila Kek 1 gene. Kek 1 encodes a cell surface protein, Kekkon-1, which inhibits epidermal growth factor receptor-mediated signalling. We localized the LRIG1 gene to chromosome band 3p14.3, a region known to be deleted in various human cancers. In the present study LRIG1 gene expression was examined in different tumour cell lines and corresponding normal tissues by real-time RT-PCR. In many tumour cell lines, LRIG1 expression appeared absent or was down regulated compared to corresponding normal tissues. The results are consistent with LRIG1 being a tumour suppressor gene in humans. However, further studies are justified to elucidate the explicit role of LRIG1 as a negative regulator of oncogenesis.

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How to Cite

Hedman, H. ., Nilsson, J. ., Guo, D., & Henriksson, R. . (2002). Is LRIG1 a Tumour Suppressor Gene at Chromosome 3p14.3?. Acta Oncologica, 41(4), 352–354. https://doi.org/10.1080/028418602760169398