Molecular characterization of an Enterovirus 71 causing neurological disease in Germany (original) (raw)

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Abstract

Enterovirus 71 (EV71) is mainly known as a cause of hand-foot-and-mouth disease (HFMD) but sometimes associated with neurological disease, even as fatal brainstem encephalitis. In Europe, EV71 infections are extremely rare, in contrast to the worldwide situation. This is the first report of molecular characterization of an EV71 strain isolated in Europe that had caused neurological disease. The german strain is closest related to sublineage B2 strains isolated in the United States, which where mainly associated with neurological disease. Phylogenetic analysis also showed that the strain must have been imported to Germany several years ago, and continues to circulate since then.

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Authors and Affiliations

1. Laboratory G. Enders and Partner and Institute for Virology, Infectology and Epidemiology, e.V., Rosenbergstrasse 85, 70193, Stuttgart, Germany
   Johannes Kehle, Christoph Metzger & Gisela Enders
2. VIROTEST Prof. Enders GmbH, Stuttgart, Germany
   Johannes Kehle, Christoph Metzger & Gisela Enders
3. Department for General Virology, University of Hohenheim, Institute for Genetics, Stuttgart, Germany
   Bernhard Roth & Artur Pfitzner

Authors

1. Johannes Kehle
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2. Bernhard Roth
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3. Christoph Metzger
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4. Artur Pfitzner
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5. Gisela Enders
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Correspondence toJohannes Kehle.

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Kehle, J., Roth, B., Metzger, C. et al. Molecular characterization of an Enterovirus 71 causing neurological disease in Germany.Journal of NeuroVirology 9, 126–128 (2003). https://doi.org/10.1080/13550280390173364

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• Received: 03 June 2002
• Revised: 18 July 2002
• Accepted: 29 August 2002
• Issue Date: January 2003
• DOI: https://doi.org/10.1080/13550280390173364

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