Enhanced Capacity of a Widespread Strain of Mycobacterium tuberculosis to Grow in Human Macrophages (original) (raw)

Journal Article

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Center for Pulmonary and Infectious Disease Control, Department of Medicine and Department of Cell Biology, University of Texas Health Center at Tyler

,

Tyler, Texas

;

Departments of Pathology and Anatomy, University of Arkansas for Medical Sciences and Medical Research Service, McClellan Memorial Veterans Hospital

,

Little Rock, Arkansas

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Center for Pulmonary and Infectious Disease Control, Department of Medicine and Department of Cell Biology, University of Texas Health Center at Tyler

,

Tyler, Texas

;

Departments of Pathology and Anatomy, University of Arkansas for Medical Sciences and Medical Research Service, McClellan Memorial Veterans Hospital

,

Little Rock, Arkansas

Search for other works by this author on:

,

Center for Pulmonary and Infectious Disease Control, Department of Medicine and Department of Cell Biology, University of Texas Health Center at Tyler

,

Tyler, Texas

;

Departments of Pathology and Anatomy, University of Arkansas for Medical Sciences and Medical Research Service, McClellan Memorial Veterans Hospital

,

Little Rock, Arkansas

Search for other works by this author on:

,

Center for Pulmonary and Infectious Disease Control, Department of Medicine and Department of Cell Biology, University of Texas Health Center at Tyler

,

Tyler, Texas

;

Departments of Pathology and Anatomy, University of Arkansas for Medical Sciences and Medical Research Service, McClellan Memorial Veterans Hospital

,

Little Rock, Arkansas

Search for other works by this author on:

,

Center for Pulmonary and Infectious Disease Control, Department of Medicine and Department of Cell Biology, University of Texas Health Center at Tyler

,

Tyler, Texas

;

Departments of Pathology and Anatomy, University of Arkansas for Medical Sciences and Medical Research Service, McClellan Memorial Veterans Hospital

,

Little Rock, Arkansas

Search for other works by this author on:

Center for Pulmonary and Infectious Disease Control, Department of Medicine and Department of Cell Biology, University of Texas Health Center at Tyler

,

Tyler, Texas

;

Departments of Pathology and Anatomy, University of Arkansas for Medical Sciences and Medical Research Service, McClellan Memorial Veterans Hospital

,

Little Rock, Arkansas

Reprints or correspondence: Dr. Peter F. Barnes, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708-3154 (pbarnes@uthct.edu).

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Received:

09 October 1998

Revision received:

08 January 1999

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Ming Zhang, Jianhua Gong, Zhenhua Yang, Buka Samten, M. Donald Cave, Peter F. Barnes, Enhanced Capacity of a Widespread Strain of Mycobacterium tuberculosis to Grow in Human Macrophages, The Journal of Infectious Diseases, Volume 179, Issue 5, May 1999, Pages 1213–1217, https://doi.org/10.1086/314738
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Abstract

To determine whether the extent of spread of Mycobacterium tuberculosis strains in the community correlated with their capacity to replicate in human macrophages, intracellular growth rates of M. tuberculosis patient isolates were measured. Strain 210 caused disease in 43 patients in central Los Angeles, 3 “small-cluster” strains caused disease in 8–23 patients, and 5 “unique” strains each caused disease in only 1 patient who was positive by sputum acid-fast smear and spent substantial amounts of time at homeless shelters that were tuberculosis transmission sites. Strain 210 isolates grew significantly more rapidly than small-cluster and unique strains in macrophages. All strains elicited production of similar amounts of tumor necrosis factor-α, interleukin (IL)-6, IL-10, and IL-12 and were equally susceptible to reactive nitrogen intermediates. It was concluded that the extensive spread of an M. tuberculosis strain correlated with its capacity to replicate rapidly in human macrophages, which may be a marker of virulence.

© 1999 by the Infectious Diseases Society of America

Topic:

• interleukin-10
• interleukin-12
• macrophages
• mycobacterium tuberculosis
• tuberculosis
• virulence
• growth rate

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