Analysis of Measles Virus Binding Sites of the CD46 Gene in Patients with Subacute Sclerosing Panencephalitis (original) (raw)
Journal Article
1
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
,
Fukuoka
Reprints or correspondence: Dr. Koichi Kusuhara, Dept. of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan ([email protected]).
Search for other works by this author on:
1
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
,
Fukuoka
Search for other works by this author on:
1
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
,
Fukuoka
Search for other works by this author on:
1
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
,
Fukuoka
Search for other works by this author on:
2
Department of Pediatrics, Osaka City University Medical School
Search for other works by this author on:
3
Division of Neurology, Kanagawa Children's Medical Center
,
Yokohama
Search for other works by this author on:
4
Division of Neurology, National Children's Hospital
,
Tokyo
Search for other works by this author on:
5
Division of Pediatrics, National Iwaki Hospital
,
Aomori
Search for other works by this author on:
6
Division of Neurology, Shizuoka Children's Hospital
,
Shizuoka
Search for other works by this author on:
7
Division of Child Neurology, Institute of Neurological Sciences, Tottori University
,
Yonago
,
Japan
Search for other works by this author on:
Received:
15 September 1999
Revision received:
27 December 1999
Cite
Koichi Kusuhara, Yuka Sasaki, Futoshi Nakao, Kenji Ihara, Hideji Hattori, Sumimasa Yamashita, Kenji Nihei, Nobuo Koide, Hideo Aiba, Kenzo Takeshita, Toshiro Hara, Analysis of Measles Virus Binding Sites of the CD46 Gene in Patients with Subacute Sclerosing Panencephalitis, The Journal of Infectious Diseases, Volume 181, Issue 4, April 2000, Pages 1447–1449, https://doi.org/10.1086/315386
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
Measles virus (MV) binding sites of the CD46 gene were sequenced in patients with subacute sclerosing panencephalitis (SSPE) and in controls. There were 3 novel polymorphisms, including C/T at nucleotide position 38 (C/T38), G/A at position 176 (G/A176), and C/T at position 453 (C/T453), at allele frequencies of .97 : .03, .99 : .01, and .97 : .03, respectively. The G/A176 polymorphism causes an Arg/Gln amino acid change within the essential binding sites of MV, whereas the C/A38 polymorphism causes a Ser/Phe change outside the MV binding sites. The C/T453 polymorphism does not produce an amino acid change. Two of the 40 SSPE patients and 2 of the 32 controls had both C/T38 and C/T453 polymorphisms in heterozygous patterns. One control subject, but no SSPE patients, had the G/A176 polymorphism in a heterozygous pattern. Thus, it is not likely that CD46 gene alteration has a role as a host susceptibility factor in the development of SSPE.
© 2000 by the Infectious Diseases Society of America
Topic:
- amino acids
- polymorphism
- binding sites
- gene frequency
- genes
- heterozygote
- measles virus
- nucleotides
- phenylalanine
- subacute sclerosing panencephalitis
- glutamine
- cd46 antigen
- host (organism)
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Analysis of Measles Virus Binding Sites of the CD46 Gene in Patients with Subacute Sclerosing Panencephalitis - 24 Hours access
EUR €39.00
GBP £33.00
USD $43.00
Rental
This article is also available for rental through DeepDyve.
Citations
Views
Altmetric
Email alerts
Related articles in PubMed
Citing articles via
More from Oxford Academic