Changes in the Composition of Circulating CD8+ T Cell Subsets during Acute Epstein-Barr and Human Immunodeficiency Virus Infections in Humans (original) (raw)

Journal Article

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1

Department of Clinical Viro-Immunology, CLB and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam at the CLB

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Department of Immunobiology, CLB and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam at the CLB

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Department of Clinical Viro-Immunology, CLB and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam at the CLB

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1

Department of Clinical Viro-Immunology, CLB and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam at the CLB

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1

Department of Clinical Viro-Immunology, CLB and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam at the CLB

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1

Department of Clinical Viro-Immunology, CLB and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam at the CLB

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Department of Clinical Viro-Immunology, CLB and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam at the CLB

3

Department of Human Retrovirology, Academic Medical Center, University of Amsterdam

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Amsterdam

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The Netherlands

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Department of Clinical Viro-Immunology, CLB and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam at the CLB

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Department of Internal Medicine, Academic Medical Center, University of Amsterdam

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Amsterdam

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The Netherlands

Reprints or correspondence: Dr. Peter Th. A. Schellekens, CLB, Dept. of Clinical Viro-Immunology, P.O. Box 9190, 1006 AD Amsterdam, The Netherlands (m_roos@clb.nl).

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Received:

29 November 1999

Revision received:

03 May 2000

Published:

01 August 2000

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Marijke Th. L. Roos, René A. W. van Lier, Dörte Hamann, Gerlinde J. Knol, Irma Verhoofstad, Debbie van Baarle, Frank Miedema, Peter Th. A. Schellekens, Changes in the Composition of Circulating CD8+ T Cell Subsets during Acute Epstein-Barr and Human Immunodeficiency Virus Infections in Humans, The Journal of Infectious Diseases, Volume 182, Issue 2, August 2000, Pages 451–458, https://doi.org/10.1086/315737
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Abstract

In response to viral infection, unprimed naive CD8+, major histocompatibility complex class I—restricted, virus-specific T cells clonally expand and differentiate into memory- and effector-type cells. Changes in CD8+ subset distribution were studied in 17 subjects with acute human immunodeficiency virus type 1 infection and in 14 subjects with acute Epstein-Barr virus (EBV) infection, with combined CD45RO, CD27, and CD28 monoclonal antibodies. A vast expansion of memory-type CD45RO+CD27+CD8+ T cells, with high expression of the cell-cycle marker Ki-67, was observed in both infections. Strikingly, CD45RO+CD27+CD28− cells increased >10-fold in acute viral infection and had high Ki-67 expression. In acute EBV infection, a substantial portion of the expanded T cells were EBV-peptide specific. These cells resided mainly in the CD45RO+CD27+ subpopulation, with most in the CD27+CD28− subpopulation. Content of perforin expression, as a measure of cytotoxic capacity, was relatively low in the CD27+CD28+ T cells and highest in the CD27−CD28− subpopulation.

© 2000 by the Infectious Diseases Society of America

Topic:

• herpesvirus 4, human
• monoclonal antibodies
• antigens, cd27
• cd28 antigens
• epstein-barr virus infections
• ki-67 antigen
• peptides
• t-lymphocyte subsets
• t-lymphocytes
• virus diseases
• infections
• memory
• viruses
• hiv infections
• perforin
• hiv-1 infection

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