Effect of Human Immunodeficiency Virus (HIV) Type 1 Envelope Subtypes A and D on Disease Progression in a Large Cohort of HIV-1—Positive Persons in Uganda (original) (raw)

Journal Article

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1

Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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Entebbe

2

Liverpool School of Tropical Medicine

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Liverpool

Reprints or correspondence: Dr. Pontiano Kaleebu,

Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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PO Box 49, Entebbe, Uganda

mrc@starcom.co.ug.

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Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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Entebbe

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Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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Entebbe

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Centre for HIV Research, University of Edinburgh

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Edinburgh

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Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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Entebbe

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Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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Entebbe

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Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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Entebbe

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Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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Entebbe

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Medical Research Council Programme on AIDS, Uganda Virus Research Institute

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Entebbe

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Imperial College of Science, Technology, and Medicine, Jefferiss Research Trust Laboratories at St. Mary's

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Norfolk Place, London, United Kingdom

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Revision received:

22 December 2001

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Pontiano Kaleebu, Neil French, Cedric Mahe, David Yirrell, Christine Watera, Fred Lyagoba, Jessica Nakiyingi, Alleluiah Rutebemberwa, Dilys Morgan, Jonathan Weber, Charles Gilks, Jimmy Whitworth, Effect of Human Immunodeficiency Virus (HIV) Type 1 Envelope Subtypes A and D on Disease Progression in a Large Cohort of HIV-1—Positive Persons in Uganda, The Journal of Infectious Diseases, Volume 185, Issue 9, 1 May 2002, Pages 1244–1250, https://doi.org/10.1086/340130
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Abstract

The effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 months, a clinical history, examination, and laboratory investigations that included CD4 cell counts were done. HIV-1 envelope subtype was assessed mainly by peptide serology supplemented by heteroduplex mobility assay and DNA sequencing. A multivariate analysis of survival was performed to assess the prognostic value of HIV-1 subtype on death. A marginal general linear model also determined the effect of subtype on CD4 cell count during follow-up. Subtype D was associated with faster progression to death (relative risk, 1.29; 95% confidence interval, 1.07–1.56; P = .009) and with a lower CD4 cell count during follow-up (P = .001), compared with subtype A, after adjusting for CD4 cell count at enrollment. In Africa, envelope subtype D is associated with faster disease progression, compared with subtype A.

© 2002 by the Infectious Diseases Society of America

Topic:

• hiv
• adult
• africa
• cd4 count determination procedure
• disease progression
• follow-up
• hiv-1
• peptides
• sequence analysis, dna
• serologic tests
• uganda
• patient prognosis
• study of serum
• mobility

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