Determining the Relative Efficacy of Highly Active Antiretroviral Therapy (original) (raw)

Journal Article

,

1Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York;

Search for other works by this author on:

,

1Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York;

Search for other works by this author on:

,

2Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico;

Search for other works by this author on:

,

1Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York;

Search for other works by this author on:

,

1Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York;

Search for other works by this author on:

,

3Gilead Sciences, Foster City, California;

Search for other works by this author on:

,

4Bristol-Myers Squibb, Wallingford, Connecticut;

Search for other works by this author on:

,

5Abbott Laboratories, Abbott Park, Illinois

Search for other works by this author on:

,

5Abbott Laboratories, Abbott Park, Illinois

Search for other works by this author on:

,

2Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico;

Search for other works by this author on:

... Show more

Received:

08 October 2002

Revision received:

04 November 2002

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Michael Louie, Christine Hogan, Michele Di Mascio, Arlene Hurley, Viviana Simon, James Rooney, Nancy Ruiz, Scott Brun, Eugene Sun, Alan S Perelson, David D Ho, Martin Markowitz, Determining the Relative Efficacy of Highly Active Antiretroviral Therapy, The Journal of Infectious Diseases, Volume 187, Issue 6, 15 March 2003, Pages 896–900, https://doi.org/10.1086/368164
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Despite the clinical benefits of combination antiviral therapy, whether maximal antiviral potency has been achieved with current drug combinations remains unclear. We studied the first phase of decay of human immunodeficiency virus type 1 (HIV-1) RNA in plasma, one early indicator of antiviral activity, after the administration of a novel combination of lopinavir/ritonavir, efavirenz, tenofovir disoproxil fumarate, and lamivudine and compared it with that observed in matched cohorts treated with alternative combination regimens. On the basis of these comparisons, we conclude that the relative potency of highly active antiretroviral therapy may be augmented by as much as 25%–30%. However, it is important to emphasize that further study is warranted to explore whether these early measurements of relative efficacy provide long-term virologic and clinical benefits. Nevertheless, we believe that optimal treatment regimens for HIV-1 have yet to be identified and that continued research to achieve this goal is warranted

© 2003 by the Infectious Diseases Society of America

Topic:

• antiretroviral therapy, highly active
• efavirenz
• antiviral agents
• drug combinations
• hiv-1
• lamivudine
• plasma
• ritonavir
• tenofovir
• lopinavir
• rna

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Determining the Relative Efficacy of Highly Active Antiretroviral Therapy - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 1,085

702 Pageviews

383 PDF Downloads

Since 1/1/2017

Citations

81 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic