Respiratory Syncytial Virus (RSV)—Induced Airway Hyperresponsiveness in Allergically Sensitized Mice Is Inhibited by Live RSV and Exacerbated by Formalin-Inactivated RSV (original) (raw)

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1

Department of Medicine, Vanderbilt University School of Medicine

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Nashville, Tennessee

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Department of Medicine, Vanderbilt University School of Medicine

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Nashville, Tennessee

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2

Department of Pathology, Vanderbilt University School of Medicine

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Nashville, Tennessee

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Department of Medicine, Vanderbilt University School of Medicine

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Nashville, Tennessee

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Department of Medicine, Vanderbilt University School of Medicine

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Nashville, Tennessee

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Department of Medicine, Vanderbilt University School of Medicine

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Nashville, Tennessee

3

Department of Microbiology and Immunology, Vanderbilt University School of Medicine

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Nashville, Tennessee

Reprints or correspondence: Dr. Barney S. Graham, Division of Infectious Disease, A-4103 MCN, Vanderbilt University Medical Center, Nashville, TN 37232-2582 (Barney.Graham@mcmail.vanderbilt.edu).

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Revision received:

24 May 2000

Published:

01 September 2000

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R. Stokes Peebles, James R. Sheller, Robert D. Collins, Kasia Jarzecka, Daphne B. Mitchell, Barney S. Graham, Respiratory Syncytial Virus (RSV)—Induced Airway Hyperresponsiveness in Allergically Sensitized Mice Is Inhibited by Live RSV and Exacerbated by Formalin-Inactivated RSV, The Journal of Infectious Diseases, Volume 182, Issue 3, September 2000, Pages 671–677, https://doi.org/10.1086/315783
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Abstract

Respiratory syncytial virus (RSV)—induced disease is associated with recurrent episodes of wheezing in children, and an effective vaccine currently is not available. The use of 2 immunizations (a formalin-inactivated, alum-precipitated RSV vaccine [FI-RSV] given intramuscularly and live RSV given intranasally [LVIN]), with a control immunization, were compared in a well-characterized model of RSV challenge, with or without concomitant allergic sensitization with ovalbumin. FI-RSV caused a significant increase in airway hyperresponsiveness in mice after RSV infection during allergic sensitization, and this was associated with an increase in type 2 cytokine production. In contrast, immunization with LVIN did not change type 2 cytokine production and protected against RSV-induced airway hyperresponsiveness in the setting of allergic sensitization. This study suggests that immune modulation with RSV vaccination can have profound effects on RSV-induced airway disease and that prevention of airway hyperresponsiveness is an important end point in vaccine development.

© 2000 by the Infectious Diseases Society of America

Topic:

• cytokine
• lung
• asthma
• immunization
• ovalbumin
• ovum
• respiratory syncytial virus infections
• respiratory syncytial virus vaccines
• respiratory syncytial viruses
• vaccines
• formaldehyde
• mice
• sensitization
• airway device
• symptom aggravating factors

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