Development of photo-crosslinkable platelet lysate-based hydrogels for 3D printing and tissue engineering (original) (raw)

Paper

, Jae Seo Lee, Haram Nah, Seung Hyeon Kim, Ho-Jin Moon, Rui L Reis, Il Keun Kwon and Dong Nyoung Heo

Published 16 August 2021 • © 2021 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Biofabrication,Volume 13,Number 4Citation Sung Jun Min et al 2021 Biofabrication 13 044102DOI 10.1088/1758-5090/ac1993

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1758-5090/13/4/044102

Abstract

Three-dimensional (3D) printing shows potential for use as an advanced technology for forming biomimetic tissue and other complex structures. However, there are limits and restrictions on selection of conventional bioinks. Here we report the first 3D-printable platelet lysate (PLMA)-based hydrogel, which consists of platelet lysate from whole blood of humans that can simulate the 3D structure of tissues and can be formed into a crosslinked hydrogel layer-by-layer to build cell-laden hydrogel constructs through methacrylated photo-polymerization. Furthermore, it can be customized for use with various tissues by controlling the physical properties according to irradiation time and concentration. In particular, different cells can be mixed and printed, and the integrity of the 3D printed structure can maintain its shape after crosslinking. The bio-ink exhibits excellent cell diffusion and proliferation at low concentrations, which improves moldability and biocompatibility. The 3D-printable PLMA bioinks may constitute a new strategy to create customized microenvironments for the repair of various tissues in vivo using materials derived from the human body.

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