Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice (original) (raw)

Journal Article

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Department of Neurology, Georg August University

Göttingen, Germany

Correspondence to: Marco Prinz, MD, Institute of Neuropathology, Georg August University, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany E-mail: mprinz@med.uni-goettingen.de

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Institute of Neuropathology, Georg August University

Göttingen, Germany

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Institute of Neuropathology, Georg August University

Göttingen, Germany

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Department of Neurophysiology and Cellular Biophysics, Institute of Physiology and Pathophysiology, Georg August University

Göttingen, Germany

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Institute of Neuropathology, Georg August University

Göttingen, Germany

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Departments of Psychiatry and Experimental Neurology, Charité-Universitätsmedizin Berlin

Berlin, Germany

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Department of Neurology, Georg August University

Göttingen, Germany

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Institute of Neuropathology, Georg August University

Göttingen, Germany

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Received:

08 February 2006

Revision received:

30 June 2006

Published:

03 August 2006

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Marija Djukic, Alexander Mildner, Hauke Schmidt, Dirk Czesnik, Wolfgang Brück, Josef Priller, Roland Nau, Marco Prinz, Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice, Brain, Volume 129, Issue 9, September 2006, Pages 2394–2403, https://doi.org/10.1093/brain/awl206
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Abstract

Previous studies have demonstrated a potential role of brain endogenous microglia and meningeal macrophages in inflammation and brain injury during bacterial meningitis. However, the contribution of previously engrafted monocytes and microglia to this process is still unknown. We therefore used genetically labelled bone marrow-derived cells from transgenic mice expressing the green fluorescent protein (GFP) under the chicken β-actin promoter to deliver fluorescently labelled monocytes to the diseased brain. Approximately 24 hours after Streptococcus pneumoniae infection, GFP-expressing parenchymal microglia changed their morphology to an activated phenotype and upregulated major histocompatibility complex class II molecules. Bacterial meningitis increased the engraftment of GFP+ monocytes and their differentiation to microglia during the post-inflammatory period, but not during acute meningitis. Importantly, these newly recruited monocytes became an integral part of the pool of parenchymal microglia and contributed to the clearance of damaged tissue by increased lysosomal activity and close location to apoptotic cells. Thus, circulating cells entering the brain such as monocytes/macrophages might provide a potential cellular target for the treatment of the tissue damage following meningitis via peripheral cell therapy.

© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Topic:

• meningitis
• macrophages
• microglia
• monocytes
• brain
• mice
• engraftment

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