Neuropathological changes in essential tremor: 33 cases compared with 21 controls (original) (raw)

Journal Article

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

,

1GH Sergievsky Center, 2Department of Neurology, 3Taub Institute for Research on Alzheimer's Disease and the Aging Brain, 4Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, 6Royal University Hospital, Saskatoon, Saskatchewan, Canada, 7Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, 8Veterans Affairs Pacific Islands Health Care System, 9Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, 10Pacific Health Research Institute and 11Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA

Search for other works by this author on:

... Show more

Revision received:

09 October 2007

Accepted:

11 October 2007

Published:

19 November 2007

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Elan D. Louis, Phyllis L. Faust, Jean-Paul G. Vonsattel, Lawrence S. Honig, Alex Rajput, Christopher A. Robinson, Ali Rajput, Rajesh Pahwa, Kelly E. Lyons, G.Webster Ross, Sarah Borden, Carol B. Moskowitz, Arlene Lawton, Nora Hernandez, Neuropathological changes in essential tremor: 33 cases compared with 21 controls, Brain, Volume 130, Issue 12, December 2007, Pages 3297–3307, https://doi.org/10.1093/brain/awm266
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Despite its being one of the most commonly observed neurological disorders, neuropathological studies of essential tremor (ET) are rare. There have been surprisingly few autopsy studies and even fewer case-control comparisons. The primary objective was to describe and quantify the pathological changes in 33 ET and 21 control brains. A secondary objective was to correlate clinical and pathological features. We examined autopsy tissue from the Essential Tremor Centralized Brain Repository. Eight (24.2%) of the 33 ET brains had Lewy bodies in the brainstem, mainly in the locus ceruleus. However, the majority of ET brains (25/33, 75.8%) had no Lewy bodies, but had pathological changes in the cerebellum. The mean number of Purkinje cells per 100× field was reduced in ET cases without Lewy bodies (6.6 ± 2.4 versus 9.6 ± 3.4, P < 0.01), and there were ∼7× more Purkinje cell torpedoes per section (12.6 ± 7.9 versus 1.7 ± 1.4, P < 0.001) compared to controls. ET cases without Lewy bodies also had degeneration of the dentate nucleus (two cases). Other findings in ET cases were Purkinje cell heterotopias and dendrite swellings. Lewy body ET cases were older than ET cases without Lewy bodies. Several trends were observed in ET cases without Lewy bodies, including a younger age of onset of tremor and higher proportions with gait difficulty and family history of ET. The pathological changes of ET seem to be heterogeneous and degenerative. The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study.

© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Topic:

• gait
• heterogeneity
• autopsy
• essential tremor
• lewy bodies
• locus ceruleus
• purkinje cells
• tremor
• brain
• brain stem
• cerebellum
• dentate nucleus

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Neuropathological changes in essential tremor: 33 cases compared with 21 controls - 24 Hours access

EUR €51.00

GBP £44.00

USD $55.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 4,371

2,860 Pageviews

1,511 PDF Downloads

Since 12/1/2016

Citations

439 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic