Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs (original) (raw)

Journal Article

,

1 Department of Medicine, McGill University, Montréal, Québec H3G 1A4, Canada

†

These authors contributed equally to this work.

Search for other works by this author on:

,

2 Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec H4P 2R2, Canada

†

These authors contributed equally to this work.

Search for other works by this author on:

,

1 Department of Medicine, McGill University, Montréal, Québec H3G 1A4, Canada

†

These authors contributed equally to this work.

Search for other works by this author on:

,

1 Department of Medicine, McGill University, Montréal, Québec H3G 1A4, Canada

2 Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec H4P 2R2, Canada

Search for other works by this author on:

,

2 Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec H4P 2R2, Canada

Search for other works by this author on:

,

2 Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec H4P 2R2, Canada

Search for other works by this author on:

,

2 Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec H4P 2R2, Canada

Search for other works by this author on:

1 Department of Medicine, McGill University, Montréal, Québec H3G 1A4, Canada

2 Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec H4P 2R2, Canada

* To whom correspondence should be addressed. Tel: +1 514 496 6318; Fax: +1 514 496 6319; Email: shi.shen@cnrc-nrc.gc.ca

Search for other works by this author on:

Received:

21 December 2007

Revision received:

19 February 2008

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Meiqun Wu, Normand Jolicoeur, Zhen Li, Linhua Zhang, Yves Fortin, Denis L'Abbe, Zhenbao Yu, Shi-Hsiang Shen, Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs, Carcinogenesis, Volume 29, Issue 9, September 2008, Pages 1710–1716, https://doi.org/10.1093/carcin/bgn073
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level to lead to mRNA degradation or repressed protein production. The expression of miRNA is deregulated in many types of cancers. To determine whether genetic alterations in miRNA genes are associated with cancers, we have systematically screened sequence variations in several hundred human miRNAs from >100 human tumor tissues and 20 cancer cell lines. We identified 8 new single-nucleotide polymorphisms (SNPs) and 14 novel mutations (or very rare SNPs) that specifically present in human cancers. These mutations/SNPs are distributed in the regions of pri-, pre- and even mature miRNAs, respectively. Importantly, whereas most of the mutations did not exert detectable effects on miRNA function, a G → A mutation at 19 nt downstream of miRNA let-7e led to a significant reduction of its expression in vivo , indicating that miRNA mutation could contribute to tumorigenesis. These data suggest that further screening for genetic variations in miRNA genes from a wide variety of human cancers should increase the discovery and identification of molecular diagnostic and therapeutic targets and complement the mutation analysis of consensus coding sequences in human cancers.

© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Topic:

• mutation
• cancer
• single nucleotide polymorphism
• genetics
• micrornas

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs - 24 Hours access

EUR €51.00

GBP £44.00

USD $55.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 1,417

978 Pageviews

439 PDF Downloads

Since 1/1/2017

Citations

130 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic