Selective Coexpression of Multiple Chemical Markers Defines Discrete Populations of Neocortical GABAergic Neurons (original) (raw)

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1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

2Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan

3Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo 102-0075, Japan

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1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

3Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo 102-0075, Japan

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1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

3Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo 102-0075, Japan

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1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

2Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan

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1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

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1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

Search for other works by this author on:

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1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

2Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan

3Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo 102-0075, Japan

Search for other works by this author on:

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1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

2Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan

3Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo 102-0075, Japan

Search for other works by this author on:

1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444-8787, Japan

2Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan

3Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo 102-0075, Japan

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Published:

10 January 2011

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Yoshiyuki Kubota, Naoki Shigematsu, Fuyuki Karube, Akio Sekigawa, Satoko Kato, Noboru Yamaguchi, Yasuharu Hirai, Mieko Morishima, Yasuo Kawaguchi, Selective Coexpression of Multiple Chemical Markers Defines Discrete Populations of Neocortical GABAergic Neurons, Cerebral Cortex, Volume 21, Issue 8, August 2011, Pages 1803–1817, https://doi.org/10.1093/cercor/bhq252
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Abstract

Whether neocortical γ-aminobutyric acid (GABA) cells are composed of a limited number of distinct classes of neuron, or whether they are continuously differentiated with much higher diversity, remains a contentious issue for the field. Most GABA cells of rat frontal cortex have at least 1 of 6 chemical markers (parvalbumin, calretinin, alpha-actinin-2, somatostatin, vasoactive intestinal polypeptide, and cholecystokinin), with each chemical class comprising several distinct neuronal subtypes having specific physiological and morphological characteristics. To better clarify GABAergic neuron diversity, we assessed the colocalization of these 6 chemical markers with corticotropin-releasing factor (CRF), neuropeptide Y (NPY), the substance P receptor (SPR), and nitric oxide synthase (NOS); these 4 additional chemical markers suggested to be expressed diversely or specifically among cortical GABA cells. We further correlated morphological and physiological characteristics of identified some chemical subclasses of inhibitory neurons. Our results reveal expression specificity of CRF, NPY, SPR, and NOS in morphologically and physiologically distinct interneuron classes. These observations support the existence of a limited number of functionally distinct subtypes of GABA cells in the neocortex.

© The Author 2011. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Topic:

• gamma-aminobutyric acid
• neurons
• neuropeptide y
• rats
• augmentative and alternative communication

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