Developmental Changes in Organization of Structural Brain Networks (original) (raw)
Journal Article
1
McConnell Brain Imaging Center
,
Montreal Neurological Institute
,
McGill University
,
Montreal, QC H3A 2B4
,
Canada,
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McConnell Brain Imaging Center
,
Montreal Neurological Institute
,
McGill University
,
Montreal, QC H3A 2B4
,
Canada,
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2
Max Planck Institute for Human Cognitive and Brain Sciences
,
Leipzig
,
Germany
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McConnell Brain Imaging Center
,
Montreal Neurological Institute
,
McGill University
,
Montreal, QC H3A 2B4
,
Canada,
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McConnell Brain Imaging Center
,
Montreal Neurological Institute
,
McGill University
,
Montreal, QC H3A 2B4
,
Canada,
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3
Department of Psychiatry
,
The Hospital for Sick Children, University of Toronto
,
Toronto, ON
,
Canada
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McConnell Brain Imaging Center
,
Montreal Neurological Institute
,
McGill University
,
Montreal, QC H3A 2B4
,
Canada,
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1
McConnell Brain Imaging Center
,
Montreal Neurological Institute
,
McGill University
,
Montreal, QC H3A 2B4
,
Canada,
Search for other works by this author on:
1
McConnell Brain Imaging Center
,
Montreal Neurological Institute
,
McGill University
,
Montreal, QC H3A 2B4
,
Canada,
Search for other works by this author on:
1
McConnell Brain Imaging Center
,
Montreal Neurological Institute
,
McGill University
,
Montreal, QC H3A 2B4
,
Canada,
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Cite
Budhachandra S. Khundrakpam, Andrew Reid, Jens Brauer, Felix Carbonell, John Lewis, Stephanie Ameis, Sherif Karama, Junki Lee, Zhang Chen, Samir Das, Alan C. Evans, Brain Development Cooperative Group, William S. Ball, Anna Weber Byars, Mark Schapiro, Wendy Bommer, April Carr, April German, Scott Dunn, Michael J. Rivkin, Deborah Waber, Robert Mulkern, Sridhar Vajapeyam, Abigail Chiverton, Peter Davis, Julie Koo, Jacki Marmor, Christine Mrakotsky, Richard Robertson, Gloria McAnulty, Michael E. Brandt, Jack M. Fletcher, Larry A. Kramer, Grace Yang, Cara McCormack, Kathleen M. Hebert, Hilda Volero, Kelly Botteron, Robert C. McKinstry, William Warren, Tomoyuki Nishino, C. Robert Almli, Richard Todd, John Constantino, James T. McCracken, Jennifer Levitt, Jeffrey Alger, Joseph O'Neil, Arthur Toga, Robert Asarnow, David Fadale, Laura Heinichen, Cedric Ireland, Dah-Jyuu Wang, Edward Moss, Robert A. Zimmerman, Brooke Bintliff, Ruth Bradford, Janice Newman, Alan C. Evans, Rozalia Arnaoutelis, G. Bruce Pike, D. Louis Collins, Gabriel Leonard, Tomas Paus, Alex Zijdenbos, Samir Das, Vladimir Fonov, Luke Fu, Jonathan Harlap, Ilana Leppert, Denise Milovan, Dario Vins, Thomas Zeffiro, John Van Meter, Nicholas Lange, Michael P. Froimowitz, Kelly Botteron, C. Robert Almli, Cheryl Rainey, Stan Henderson, Tomoyuki Nishino, William Warren, Jennifer L. Edwards, Diane Dubois, Karla Smith, Tish Singer, Aaron A. Wilber, Carlo Pierpaoli, Peter J. Basser, Lin-Ching Chang, Chen Guan Koay, Lindsay Walker, Lisa Freund, Judith Rumsey, Lauren Baskir, Laurence Stanford, Karen Sirocco, Katrina Gwinn-Hardy, Giovanna Spinella, James T. McCracken, Jeffry R. Alger, Jennifer Levitt, Joseph O'Neill, Developmental Changes in Organization of Structural Brain Networks, Cerebral Cortex, Volume 23, Issue 9, September 2013, Pages 2072–2085, https://doi.org/10.1093/cercor/bhs187
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Abstract
Recent findings from developmental neuroimaging studies suggest that the enhancement of cognitive processes during development may be the result of a fine-tuning of the structural and functional organization of brain with maturation. However, the details regarding the developmental trajectory of large-scale structural brain networks are not yet understood. Here, we used graph theory to examine developmental changes in the organization of structural brain networks in 203 normally growing children and adolescents. Structural brain networks were constructed using interregional correlations in cortical thickness for 4 age groups (early childhood: 4.8–8.4 year; late childhood: 8.5–11.3 year; early adolescence: 11.4–14.7 year; late adolescence: 14.8–18.3 year). Late childhood showed prominent changes in topological properties, specifically a significant reduction in local efficiency, modularity, and increased global efficiency, suggesting a shift of topological organization toward a more random configuration. An increase in number and span of distribution of connector hubs was found in this age group. Finally, inter-regional connectivity analysis and graph-theoretic measures indicated early maturation of primary sensorimotor regions and protracted development of higher order association and paralimbic regions. Our finding reveals a time window of plasticity occurring during late childhood which may accommodate crucial changes during puberty and the new developmental tasks that an adolescent faces.
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