MAR1—A REGULATOR OF THE HM a AND HMα LOCI IN SACCHAROMYCES CEREVISIAE (original) (raw)
Journal Article
,
Department of Genetics
, University of California Berkeley, California 94720
Present address: Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, New York 11724.
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,
Department of Genetics
, University of California Berkeley, California 94720
Search for other works by this author on:
Department of Genetics
, University of California Berkeley, California 94720
Search for other works by this author on:
Received:
29 September 1978
Published:
01 September 1979
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ABSTRACT
A mutation in the MAR1 (mating-type regulator) locus causing sterility in Saccharomyces cerevisiae is reported. The mutation maps on the left arm of linkage group IV between trp1 and cdc2 at a distance of about 27 CM from _trp_1 and about 31 cM from _cdc_2. Haploid strains with genotype _MAT_α _HM_α HMa mar1-1 and _MAT_a _HM_α _HM_a mar1-1 are sterile. However, _MAT_α _hm_α _HM_a mar1-1 and _MAT_a _HM_α _hm_a mar1-1 strains exhibit a and a mating type, respectively. The sterile strains can be "rare mated" with standard strains as a consequence of mutational changes at _HM_a and _HM_α. It is proposed that the MAR1 locus blocks the expression of _MAT_α and _MAT_a information thought to exist at _HM_a and _HM_α loci, respectively (HICKS, STRATHERN and HERSKOWITZ, 1977). In a mar1-1 mutant, the expression of both _HM_α and _HM_a information leads to a nonmating phenotype similar to that of _MAT_a/_MAT_α diploids. The genetic evidence reported here is consistent with a central feature of the "cassette model", namely that _HM_α and _hm_a carry _MAT_a information and _HM_a and _hm_α carry _MAT_α information.
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© Genetics 1979
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