Acute Loading and Aging Effects on Myostatin Pathway Biomarkers in Human Skeletal Muscle After Three Sequential Bouts of Resistance Exercise (original) (raw)

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1School of Medicine and Applied Sciences, Faculty of Sciences, Engineering, and Health, Institute for Health and Social Science Research, Central Queensland University, Rockhampton, Australia

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2Department of Biomedical Science, University of Missouri-Columbia

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3Department of Health and Exercise Science, University of Oklahoma, Norman

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3Department of Health and Exercise Science, University of Oklahoma, Norman

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3Department of Health and Exercise Science, University of Oklahoma, Norman

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3Department of Health and Exercise Science, University of Oklahoma, Norman

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3Department of Health and Exercise Science, University of Oklahoma, Norman

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3Department of Health and Exercise Science, University of Oklahoma, Norman

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Received:

24 November 2010

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Vincent J. Dalbo, Michael D. Roberts, Kyle L. Sunderland, Chris N. Poole, Jeff R. Stout, Travis W. Beck, Mike Bemben, Chad M. Kerksick, Acute Loading and Aging Effects on Myostatin Pathway Biomarkers in Human Skeletal Muscle After Three Sequential Bouts of Resistance Exercise, The Journals of Gerontology: Series A, Volume 66A, Issue 8, August 2011, Pages 855–865, https://doi.org/10.1093/gerona/glr091
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Abstract

To determine the influence of age and resistance exercise on myostatin pathway–related genes, younger (n = 10; 28 ± 5 years) and older (n = 10; 68 ± 6 years) men underwent four testing conditions (T1–T4). A baseline (T1) muscle sample was obtained, whereas the second and third biopsies were obtained 48 hours following the first and second training sessions (T2, T3), and a final biopsy was taken 24 hours following T3. The training sessions consisted of 3 sets of 10 repetitions (80% of one repetition maximum) on leg press, hack squat, and leg extension exercises. Follistatin (FST) messenger RNA was greater in older compared with younger men at T1 and T2 (p < .05). Follistatin-like 3 (FSTL3) messenger RNA was greater in older compared with younger men at T1 and T4 (p < .05). In older men, there was a significant decrease in myostatin (MSTN) messenger RNA at T4 (p < .05). Older men contained less active (Ser-425 phosphorylated) SMAD3 (p-SMAD3) protein than younger men at T3 and T4 (p < ._0_5).Although it is well known that younger individuals possess a greater hypertrophic potential to resistance exercise, it appears that older individuals may paradoxically possess a more favorable resistance exercise response regarding myostatin pathway–related genes and a protein marker of pathway activity. Future research is warranted to examine the physiological significance of this age-dependent mechanism.

© The Author 2011. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Topic:

• aging
• biopsy
• exercise
• biological markers
• genes
• skeletal muscles
• rna, messenger
• leg
• follistatin
• resistive exercise
• older adult
• smad3 gene
• transverse spin relaxation time

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